XRN2 promotes EMT and metastasis through regulating maturation of miR-10a
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DOI: 10.1038/onc.2017.39
Abstract: MicroRNAs (miRNAs) have been proposed as critical regulatory molecules in the epithelial–mesenchymal transition (EMT) program. However, the roles of mature miRNA biogenesis during EMT process needs to be defined. Here we determined that increased expression… read more here.
Keywords: xrn2; metastasis; xrn2 promotes; promotes emt ... See more keywords
Abstract 1286: UNC5B promotes EMT and metastasis of pancreatic adenocarcinomas and expresses different isoforms that impact sensitivity to Netrin-1 blockade
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1286
Abstract: The axonal guidance receptor UNC5B is considered to be a tumor suppressor because it promotes apoptosis in the absence of its protein ligand, NTN1. But we find that UNC5B is not a tumor suppressor of… read more here.
Keywords: metastasis; promotes emt; pancreatic adenocarcinomas; unc5b promotes ... See more keywords
Transcription factor E2F1 promotes EMT by regulating ZEB2 in small cell lung cancer
Sign Up to like & getrecommendations! Published in 2017 at "BMC Cancer"
DOI: 10.1186/s12885-017-3701-y
Abstract: BackgroundEpithelial-mesenchymal transition (EMT) is an early event in tumour invasion and metastasis, and widespread and distant metastasis at early stages is the typical biological behaviour in small cell lung cancer (SCLC). Our previous reports showed… read more here.
Keywords: zeb2; e2f1 promotes; e2f1; expression ... See more keywords