FHL1 promotes glioblastoma aggressiveness through regulating EGFR expression
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13955
Abstract: The four‐and‐a‐half LIM domain protein 1 (FHL1) plays a key role in multiple cancers. Here, we characterized its role in glioblastoma (GBM), the most common and incurable form of brain cancer. Overexpression of FHL1 promotes… read more here.
Keywords: glioblastoma aggressiveness; promotes glioblastoma; egfr expression; fhl1 promotes ... See more keywords
LRIG2 promotes glioblastoma progression by modulating innate antitumor immunity through macrophage infiltration and polarization
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-004452
Abstract: Background Glioblastoma (GBM) is the most common malignant brain tumor with poor clinical outcomes. Immunotherapy has recently been an attractive and promising treatment of extracranial malignancies, however, most of clinical trials for GBM immunotherapy failed… read more here.
Keywords: lrig2 promotes; progression; gbm; lrig2 ... See more keywords
GRIK1 promotes glioblastoma malignancy and is a novel prognostic factor of poor prognosis
Sign Up to like & getrecommendations! Published in 2024 at "Oncology Research"
DOI: 10.32604/or.2023.043391
Abstract: Primary tumors of the central nervous system (CNS) are classified into over 100 different histological types. The most common type of glioma is derived from astrocytes, and the most invasive glioblastoma (WHO IV) accounts for… read more here.
Keywords: poor prognosis; promotes glioblastoma; grik1 promotes; prognosis ... See more keywords