Macrophage migration inhibitory factor promotes glucocorticoid resistance of neutrophilic inflammation in a murine model of severe asthma.
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DOI: 10.1136/thorax-2021-218555
Abstract: BACKGROUND Severe neutrophilic asthma is resistant to treatment with glucocorticoids. The immunomodulatory protein macrophage migration inhibitory factor (MIF) promotes neutrophil recruitment to the lung and antagonises responses to glucocorticoids. We hypothesised that MIF promotes glucocorticoid… read more here.
Keywords: inflammation; neutrophilic inflammation; glucocorticoid resistance; mif ... See more keywords