p66Shc promotes HCC progression in the tumor microenvironment via STAT3 signaling.
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DOI: 10.1016/j.yexcr.2019.111550
Abstract: The development of hepatocellular carcinoma (HCC) is strongly associated with chronic inflammation. p66Shc is an oxidase previously shown to promote androgen-independent cell growth through generation of reactive oxygen species. However, the importance and biologic functions… read more here.
Keywords: hcc; promotes hcc; stat3; p66shc promotes ... See more keywords
Abstract 1109: CPAP promotes HCC angiogenesis and metastasis via interacting with and enhancing STAT3 signaling
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DOI: 10.1158/1538-7445.sabcs18-1109
Abstract: Centrosomal P4.1-associated protein (CPAP) is a centrosomal protein and can as a transcriptional coactivator of STAT5 and NF-κB in cancer. Our previous studies indicated that CPAP is overexpressed in tumor tissue and can increase TNFα-mediated… read more here.
Keywords: metastasis; cpap promotes; cpap; angiogenesis ... See more keywords