Upregulation of PD‐L1 by SARS‐CoV‐2 promotes immune evasion
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28478
Abstract: Patients with severe COVID‐19 often suffer from lymphopenia, which is linked to T‐cell sequestration, cytokine storm, and mortality. However, it remains largely unknown how severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) induces lymphopenia. Here, we… read more here.
Keywords: immune evasion; cov promotes; promotes immune; infected cells ... See more keywords
α2,6-Sialylation promotes immune escape in hepatocarcinoma cells by regulating T cell functions and CD147/MMP signaling
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Physiology and Biochemistry"
DOI: 10.1007/s13105-019-00674-8
Abstract: Altered glycosylation is a common feature of cancer cells and plays an important role in tumor progression. β-Galactoside α2-6-sialyltransferase 1 (ST6Gal-I) is the critical sialyltransferase responsible for the addition of α2-6-sialic acid to the terminal… read more here.
Keywords: escape hepatocarcinoma; escape; immune escape; promotes immune ... See more keywords
Polyunsaturated Fatty Acid–Bound α-Fetoprotein Promotes Immune Suppression by Altering Human Dendritic Cell Metabolism
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/0008-5472.can-22-3551
Abstract: α-Fetoprotein (AFP) is a secreted tumor protein and biomarker with impact on immunity. Fatty acid–bound AFP promotes immune suppression by skewing human dendritic cell metabolism toward glycolysis and reduced immune stimulation. read more here.
Keywords: immune suppression; human dendritic; promotes immune; acid bound ... See more keywords
Microbial Inosine Promotes Immune-Checkpoint Blockade Response in Mice.
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DOI: 10.1158/2159-8290.cd-rw2020-120
Abstract: Inosine produced by the gut microbe Bifidobacterium pseudolongum enhanced anti-CTLA4's efficacy. read more here.
Keywords: immune checkpoint; inosine promotes; promotes immune; checkpoint blockade ... See more keywords