ER Stress Promotes Inflammation through Re-wIREd Macrophages in Obesity.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular cell"
DOI: 10.1016/j.molcel.2017.05.037
Abstract: A new mechanism linking ER dysfunction to metabolic inflammation is discovered in a recent study by Shan et al. (2017), which demonstrated ER stress-induced rewiring of adipose tissue macrophage polarization by IRE1α activation, leading to impaired… read more here.
Keywords: wired macrophages; stress promotes; inflammation; inflammation wired ... See more keywords
APPL2 Promotes Inflammation in Mouse Liver by Negative Regulation of Adiponectin Signaling
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DOI: 10.2337/db18-1982-p
Abstract: Adiponectin is an insulin sensitizer that exerts antidiabetes and anti-inflammation functions. Adiponectin signaling is negatively regulated by the adaptor protein APPL2 in cells, yet the in vivo roles of APPL2 remains largely unknown. In this… read more here.
Keywords: adiponectin signaling; appl2 promotes; inflammation; promotes inflammation ... See more keywords
Ginkgolic acid promotes inflammation and macrophage apoptosis via SUMOylation and NF-κB pathways in sepsis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.1108882
Abstract: Background Excessive inflammation and increased apoptosis of macrophages contribute to organ damage and poor prognosis of sepsis. Ginkgolic acid (GA) is a natural constituent extracted from the leaves of Ginkgo biloba, that can regulate inflammation… read more here.
Keywords: apoptosis; sumoylation; inflammation macrophage; promotes inflammation ... See more keywords