Cytosolic TGM2 promotes malignant progression in gastric cancer by suppressing the TRIM21‐mediated ubiquitination/degradation of STAT1 in a GTP binding‐dependent modality
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Communications"
DOI: 10.1002/cac2.12386
Abstract: Previous studies have revealed the critical role of transglutaminase 2 (TGM2) as a potential therapeutic target in cancers, but the oncogenic roles and underlying mechanisms of TGM2 in gastric cancer (GC) are not fully understood.… read more here.
Keywords: tgm2 promotes; malignant progression; cytosolic tgm2; promotes malignant ... See more keywords
HOXD13 promotes the malignant progression of colon cancer by upregulating PTPRN2
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Medicine"
DOI: 10.1002/cam4.4078
Abstract: The homeobox (HOX) family plays an important role in multi‐biological processes, such as morphogenesis and tumors. However, the function of HOXD13 in colon cancer remains unclear. read more here.
Keywords: hoxd13 promotes; malignant progression; colon cancer; cancer ... See more keywords
HEIH Promotes Malignant Progression of Gastric Cancer by Regulating STAT3-Mediated Autophagy and Glycolysis
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/2634526
Abstract: To study the clinical value of HEIH hyperexpression in gastric cancer and the molecular mechanism of promoting malignant proliferation of gastric cancer cells, qRT-PCR was used to detect the expression of HEIH in gastric cancer… read more here.
Keywords: proliferation; heih promotes; promotes malignant; gastric cancer ... See more keywords
TRIM65 Promotes Malignant Cell Behaviors in Triple-Negative Breast Cancer by Impairing the Stability of LATS1 Protein
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DOI: 10.1155/2022/4374978
Abstract: TNBC is a malignant tumor that easily relapses and metastasizes, with a poor prognosis in women. Ubiquitination plays a key role in promoting the tumor process. In various tumors, TRIM65 can affect malignant biological tumor… read more here.
Keywords: promotes malignant; trim65; tnbc; lats1 protein ... See more keywords
Redistribution of EZH2 promotes malignant phenotypes by rewiring developmental programmes
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DOI: 10.15252/embr.201948155
Abstract: Epigenetic regulators are often hijacked by cancer cells to sustain malignant phenotypes. How cells repurpose key regulators of cell identity as tumour‐promoting factors is unclear. The antithetic role of the Polycomb component EZH2 in normal… read more here.
Keywords: ezh2 promotes; rewiring developmental; phenotypes rewiring; malignant phenotypes ... See more keywords