Kinesin-5 Promotes Microtubule Nucleation and Assembly by Stabilizing a Lattice-Competent Conformation of Tubulin
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DOI: 10.1016/j.cub.2019.05.075
Abstract: Besides sliding apart antiparallel microtubules during spindle elongation, the mitotic kinesin-5, Eg5, promotes microtubule polymerization, emphasizing its importance in mitotic spindle length control. Here, we characterize the Eg5 microtubule polymerase mechanism by assessing motor-induced changes… read more here.
Keywords: microtubule nucleation; conformation tubulin; promotes microtubule; kinesin ... See more keywords