IL-6 promotes nuclear translocation of HIF-1α to aggravate chemoresistance of ovarian cancer cells.
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DOI: 10.1016/j.ejphar.2020.173817
Abstract: The inflammatory milieu in tumor modulates the resistance to the conventional antitumoral therapies. Interleukin-6 (IL-6), a pleiotropic pro-inflammatory cytokine and a crucial mediator of tumor development, has been targeted as a therapeutic strategy to overcome… read more here.
Keywords: hif; chemoresistance; translocation hif; promotes nuclear ... See more keywords