Rif1 promotes a repressive chromatin state to safeguard against endogenous retrovirus activation
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DOI: 10.1093/nar/gkx884
Abstract: Abstract Transposable elements, including endogenous retroviruses (ERVs), constitute a large fraction of the mammalian genome. They are transcriptionally silenced during early development to protect genome integrity and aberrant transcription. However, the mechanisms that control their… read more here.
Keywords: rif1; chromatin state; promotes repressive; activation ... See more keywords