The anaphase‐promoting complex: A key mitotic regulator associated with somatic mutations occurring in cancer
Sign Up to like & getrecommendations! Published in 2019 at "Genes"
DOI: 10.1002/gcc.22820
Abstract: The anaphase‐promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that helps control chromosome separation and exit from mitosis in many different kinds of organisms, including yeast, flies, worms, and humans. This review represents a new… read more here.
Keywords: anaphase promoting; complex key; apc subunits; apc ... See more keywords
Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL11[OPEN]
Sign Up to like & getrecommendations! Published in 2017 at "Plant Physiology"
DOI: 10.1104/pp.17.00785
Abstract: Phenotypic characterization of Anaphase Promoting Complex/Cyclosome Inhibitors reveals tissue-dependent roles for the APC/CCCS52A1 and APC/CCCS52A2 complexes. The endocycle represents a modified mitotic cell cycle that in plants is often coupled to cell enlargement and differentiation.… read more here.
Keywords: anaphase promoting; complex cyclosome; promoting complex; apc ... See more keywords
APC/C-Cdh1-targeted substrates as potential therapies for Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1086540
Abstract: Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder and the main cause of dementia in the elderly. The disease has a high impact on individuals and their families and represents a growing public health… read more here.
Keywords: promoting complex; cdh1; disease; alzheimer disease ... See more keywords
Activating the Anaphase Promoting Complex to Enhance Genomic Stability and Prolong Lifespan
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DOI: 10.3390/ijms19071888
Abstract: In aging cells, genomic instability is now recognized as a hallmark event. Throughout life, cells encounter multiple endogenous and exogenous DNA damaging events that are mostly repaired, but inevitably DNA mutations, chromosome rearrangements, and epigenetic… read more here.
Keywords: anaphase promoting; genomic instability; response; genomic stability ... See more keywords