Primary Tr1 cells from metastatic melanoma eliminate tumor-promoting macrophages through granzyme B- and perforin-dependent mechanisms
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DOI: 10.1177/1010428317697554
Abstract: In malignant melanoma, tumor-associated macrophages play multiple roles in promoting tumor growth, such as inducing the transformation of melanocytes under ultraviolet irradiation, increasing angiogenesis in melanomas, and suppressing antitumor immunity. Because granzyme B- and perforin-expressing… read more here.
Keywords: melanoma; granzyme perforin; tr1 cells; promoting macrophages ... See more keywords