Hippo kinase NDR2 inhibits IL‐17 signaling by promoting Smurf1‐mediated MEKK2 ubiquitination and degradation
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DOI: 10.1016/j.molimm.2018.10.005
Abstract: HighlightsNDR2 knockdown promotes IL‐17‐induced inflammation by activation of ERK, p38 and NF‐&kgr;B.NDR2 interacts with Smurf1 and MEKK2, and promotes Smurf1‐mediated k48‐linked ubiquitination of MEKK2.MEKK2 positively regulates IL‐17‐induced inflammation while Smurf1 negatively regulates IL‐17‐induced inflammation. Abstract… read more here.
Keywords: smurf1; mekk2 ubiquitination; inflammation; promoting smurf1 ... See more keywords