Ketosis-Prone Diabetes (Flatbush Diabetes): an Emerging Worldwide Clinically Important Entity
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DOI: 10.1007/s11892-018-1075-4
Abstract: Purpose of ReviewKetosis-prone diabetes or Flatbush diabetes has been widely recognized as a clinical entity since 1984. Most of the early clinical studies focused on African American or Afro-Caribbean individuals. It is now being recognized… read more here.
Keywords: prone diabetes; ketosis prone; flatbush diabetes; entity ... See more keywords
Elevated unmethylated and methylated insulin DNA are unique markers of A+β+ ketosis prone diabetes.
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DOI: 10.1016/j.jdiacomp.2017.10.013
Abstract: A+β+ ketosis prone diabetes (KPD) is associated with slowly progressive autoimmune beta cell destruction. Plasma unmethylated and methylated insulin DNA (biomarkers of ongoing beta cell damage and systemic inflammation, respectively) were elevated in A+β+ KPD… read more here.
Keywords: prone diabetes; ketosis prone; methylated insulin; unmethylated methylated ... See more keywords
Ketosis-prone diabetes mellitus: A phenotype that hospitalists need to understand
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DOI: 10.12998/wjcc.v10.i30.10867
Abstract: Diabetes has been classified mainly into types 1 and 2. Some type 2 diabetes patients, when developing ketosis, have been labeled as having atypical diabetes. Lately, syndromes of ketosis-prone diabetes, primarily in patients who we… read more here.
Keywords: diabetes mellitus; prone diabetes; mellitus phenotype; ketosis prone ... See more keywords
Metabolomics Profiling of Patients With A−β+ Ketosis-Prone Diabetes During Diabetic Ketoacidosis
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DOI: 10.2337/db21-0066
Abstract: When stable and near-normoglycemic, patients with “A−β+” ketosis-prone diabetes (KPD) manifest accelerated leucine catabolism and blunted ketone oxidation, which may underlie their proclivity to develop diabetic ketoacidosis (DKA). To understand metabolic derangements in A−β+ KPD… read more here.
Keywords: prone diabetes; patients ketosis; diabetic ketoacidosis; ketosis prone ... See more keywords
Response to Comment on Mulukutla et al. Autoantibodies to the IA-2 Extracellular Domain Refine the Definition of “A+” Subtypes of Ketosis-Prone Diabetes. Diabetes Care 2018;41:2637–2640
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DOI: 10.2337/dci19-0007
Abstract: We thank Dr. Heneberg (1) for the comments regarding our article (2) describing autoantibody responses to the IA-2 extracellular domain in ketosis-prone diabetes (KPD). We agree that the intracellular domain of the neuroendocrine autoantigen IA-2… read more here.
Keywords: prone diabetes; diabetes care; ketosis prone; extracellular domain ... See more keywords