Ultraviolet light induces increased T cell activation in lupus-prone mice via type I IFN-dependent inhibition of T regulatory cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2019.06.002
Abstract: Ultraviolet (UV) light is a known trigger of skin and possibly systemic inflammation in systemic lupus erythematosus (SLE) patients. Although type I interferons (IFN) are upregulated in SLE skin after UV exposure, the mechanisms to… read more here.
Keywords: lupus prone; type ifn; mice; prone mice ... See more keywords
Upadacitinib in MTX-naive RA
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Rheumatology"
DOI: 10.1038/s41584-020-0479-0
Abstract: Changes in the gut microbiota have previously been associated with systemic lupus erythematosus (SLE) in humans and in mouse models of the disease, as have changes in the metabolism of tryptophan, which requires microbial involvement.… read more here.
Keywords: tryptophan; lupus prone; mice; prone mice ... See more keywords
CD3+ B-1a Cells as a Mediator of Disease Progression in Autoimmune-Prone Mice
Sign Up to like & getrecommendations! Published in 2018 at "Mediators of Inflammation"
DOI: 10.1155/2018/9289417
Abstract: B-1a cells are distinguishable from conventional B cells, which are designated B-2 cells, on the basis of their developmental origin, surface marker expression, and functions. In addition to the unique expression of the CD5 antigen,… read more here.
Keywords: prone mice; autoimmune prone; mice; disease progression ... See more keywords
Metabolic preconditioning in CD4+ T cells restores inducible immune tolerance in lupus-prone mice
Sign Up to like & getrecommendations! Published in 2021 at "JCI Insight"
DOI: 10.1172/jci.insight.143245
Abstract: Autoimmune disease has presented an insurmountable barrier to restoration of durable immune tolerance. Previous studies indicate that chronic therapy with metabolic inhibitors can reduce autoimmune inflammation, but it remains unknown whether acute metabolic modulation enables… read more here.
Keywords: tolerance; immune tolerance; lupus prone; prone mice ... See more keywords
Heterogeneous Development of β-Cell Populations in Diabetes-Resistant and -Susceptible Mice
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes"
DOI: 10.2337/db21-1030
Abstract: Progressive dysfunction and failure of insulin-releasing β-cells are a hallmark of type 2 diabetes (T2D). To study mechanisms of β-cell loss in T2D, we performed islet single-cell RNA sequencing of two obese mouse strains differing… read more here.
Keywords: cell; diabetes prone; development; prone mice ... See more keywords
Oxidized Hemoglobin Is Antigenic and Immunogenic in Lupus
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.00732
Abstract: Hemolysis-associated anemia is characteristic of diseases such as atherosclerosis, lupus, malaria, and leishmaniasis; the toxic effects of free hemoglobin (Hb) have been extensively described. This study was based on the premise that release of this… read more here.
Keywords: lupus prone; oxidized hemoglobin; prone mice; lupus ... See more keywords
Rapid Induction of Pulmonary Inflammation, Autoimmune Gene Expression, and Ectopic Lymphoid Neogenesis Following Acute Silica Exposure in Lupus-Prone Mice
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.635138
Abstract: Occupational exposure to crystalline silica (cSiO2) is etiologically associated with systemic lupus erythematosus (lupus) and other autoimmune diseases. cSiO2's autoimmune effects in humans can be mimicked chronically in female lupus-prone NZBWF1 mice following repeated exposure… read more here.
Keywords: lupus prone; inflammation; exposure; csio2 ... See more keywords
Silica Induction of Diverse Inflammatory Proteome in Lungs of Lupus-Prone Mice Quelled by Dietary Docosahexaenoic Acid Supplementation
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.781446
Abstract: Repeated short-term intranasal instillation of lupus-prone mice with crystalline silica (cSiO2) induces inflammatory gene expression and ectopic lymphoid neogenesis in the lung, leading to early onset of systemic autoimmunity and rapid progression to glomerulonephritis. These… read more here.
Keywords: prone mice; supplementation; dha; lupus prone ... See more keywords