Antigenic Variation in the Lyme Spirochete: Insights into Recombinational Switching with a Suggested Role for Error-Prone Repair.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.04.117
Abstract: The Lyme disease spirochete, Borrelia burgdorferi, uses antigenic variation as a strategy to evade the host's acquired immune response. New variants of surface-localized VlsE are generated efficiently by unidirectional recombination from 15 unexpressed vls cassettes… read more here.
Keywords: prone repair; variation; antigenic variation; recombinational switching ... See more keywords
The IgH Eµ-MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1030813
Abstract: Two scaffold/matrix attachment regions (5’- and 3’-MARsEμ) flank the intronic core enhancer (cEμ) within the immunoglobulin heavy chain locus (IgH). Besides their conservation in mice and humans, the physiological role of MARsEμ is still unclear… read more here.
Keywords: error prone; somatic hypermutation; prone repair; repair ... See more keywords