Nanoparticle-based "Two-pronged" approach to regress atherosclerosis by simultaneous modulation of cholesterol influx and efflux.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.120333
Abstract: Reduction of lipoprotein uptake by macrophages and stimulation of cholesterol efflux are two essential steps required for atherosclerotic plaque regression. We used the optimized mannose-functionalized dendrimeric nanoparticle (mDNP)-based platform for macrophage-specific delivery of therapeutics to… read more here.
Keywords: lxr; two pronged; delivery; cholesterol ... See more keywords
Abstract P-402: A THREE PRONGED APPROACH TO IMPROVING ADVANCE CARE PLANNING AND END OF LIFE DECISION MAKING FOR PATIENTS WITH LIFE LIMITING CONDITIONS ADMITTED TO PICU
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric Critical Care Medicine"
DOI: 10.1097/01.pcc.0000537859.14793.d8
Abstract: We randomly assigned children 5 cm diameter and those with active infection were excluded. The respective dressing was changed when soiled, for a maximum period of 8 weeks or till healthy granulation tissue appeared. Major… read more here.
Keywords: three pronged; abstract 402; 402 three; care ... See more keywords
Senolytics and Senostatics: A Two-Pronged Approach to Target Cellular Senescence for Delaying Aging and Age-Related Diseases
Sign Up to like & getrecommendations! Published in 2019 at "Molecules and Cells"
DOI: 10.14348/molcells.2019.0298
Abstract: Aging is the most important single risk factor for many chronic diseases such as cancer, metabolic syndrome, and neurodegenerative disorders. Targeting aging itself might, therefore, be a better strategy than targeting each chronic disease individually… read more here.
Keywords: two pronged; senolytics senostatics; pronged approach; senescence ... See more keywords