The human brain NGF metabolic pathway is impaired in the pre-clinical and clinical continuum of Alzheimers disease
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Psychiatry"
DOI: 10.1038/s41380-020-0797-2
Abstract: The NGF metabolic pathway entails the proteins that mature pro-nerve growth factor (proNGF) to NGF and those that degrade NGF. Basal forebrain cholinergic neurons require NGF for maintenance of cholinergic phenotype, are critical for cognition,… read more here.
Keywords: metabolic pathway; prongf; pathology; ngf metabolic ... See more keywords
ProNGF Drives Localized and Cell Selective Parvalbumin Interneuron and Perineuronal Net Depletion in the Dentate Gyrus of Transgenic Mice
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DOI: 10.3389/fnmol.2017.00020
Abstract: ProNGF, the precursor of mature Nerve Growth Factor (NGF), is the most abundant NGF form in the brain and increases markedly in the cortex in Alzheimer's Disease (AD), relative to mature NGF. A large body… read more here.
Keywords: prongf; interneuron perineuronal; tgprongf mice; parvalbumin interneuron ... See more keywords
The NGF R100W Mutation, Associated with Hereditary Sensory Autonomic Neuropathy Type V, Specifically Affects the Binding Energetic Landscapes of NGF and of Its Precursor proNGF and p75NTR
Sign Up to like & getrecommendations! Published in 2023 at "Biology"
DOI: 10.3390/biology12030364
Abstract: Simple Summary A point mutation in the Nerve Growth factor gene (leading to the amino acid substitution R100W), causing Hereditary Sensory and Autonomic Neuropathy type V, a condition that primarily affects the sensory nerve cells,… read more here.
Keywords: hereditary sensory; sensory autonomic; r100w mutation; mutation ... See more keywords