Silk Protein Bioresorbable, Drug-Eluting Ear Tubes: Proof-of-Concept.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201801409
Abstract: Otitis media with effusion (OEM) is a common pediatric pathology treated with topical fluoroquinolones (ear drops) and tympanoplasty tube, also referred to as ear tube, implantation for middle ear drainage. Commercially available ear tubes are… read more here.
Keywords: ear tubes; drug eluting; drug; silk ... See more keywords
An agile, data‐driven approach for target selection in rTMS therapy for anxiety symptoms: Proof of concept and preliminary data for two novel targets
Sign Up to like & getrecommendations! Published in 2023 at "Brain and Behavior"
DOI: 10.1002/brb3.2914
Abstract: Data‐driven approaches to transcranial magnetic stimulation (TMS) might yield more consistent and symptom‐specific results based on individualized functional connectivity analyses compared to previous traditional approaches due to more precise targeting. We provide a proof of… read more here.
Keywords: agile data; proof concept; data driven; target selection ... See more keywords
Structure of proof of concept studies that precede a nonalcoholic steatohepatitis development program
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.560
Abstract: Surrogate endpoints for clinical proof of concept (POC) trials in nonalcoholic steatohepatitis (NASH) are based upon expert pathological review of liver biopsies. During early development, these long‐term POC studies (≥48 weeks) add cost and time… read more here.
Keywords: proof concept; poc; development; nonalcoholic steatohepatitis ... See more keywords
A Machine Learning Approach for Handling Big Data Produced by High Resolution Mass Spectrometry after Data Independent Acquisition of Small Molecules - Proof of Concept Study Using an Artificial Neural Network for Sample Classification.
Sign Up to like & getrecommendations! Published in 2020 at "Drug testing and analysis"
DOI: 10.1002/dta.2775
Abstract: Liquid chromatography coupled to high-resolution mass spectrometry (HRMS) enables data independent acquisition (DIA) and untargeted screening. However, to avoid the handling of the resulting large dataset, most laboratories in that field still use targeted screening… read more here.
Keywords: machine; high resolution; machine learning; proof concept ... See more keywords
Nitrates in combination with hydralazine in cardiorenal syndrome: a randomized controlled proof‐of‐concept study
Sign Up to like & getrecommendations! Published in 2020 at "ESC Heart Failure"
DOI: 10.1002/ehf2.13076
Abstract: Cardiorenal syndrome (CRS) is a common problem of great morbidity and mortality. Hydralazine–isosorbide dinitrate (H‐ISDN) may be used in renal failure and may improve exercise capacity in heart failure (HF). Our proof‐of‐concept study aimed to… read more here.
Keywords: proof concept; cardiorenal syndrome; concept study;
Proof‐of‐concept evidence for trimodal simultaneous investigation of human brain function
Sign Up to like & getrecommendations! Published in 2021 at "Human Brain Mapping"
DOI: 10.1002/hbm.25541
Abstract: The link between spatial (where) and temporal (when) aspects of the neural correlates of most psychological phenomena is not clear. Elucidation of this relation, which is crucial to fully understand human brain function, requires integration… read more here.
Keywords: concept evidence; human brain; brain function; proof concept ... See more keywords
Decoding phonation with artificial intelligence (DeP AI): Proof of concept
Sign Up to like & getrecommendations! Published in 2019 at "Laryngoscope Investigative Otolaryngology"
DOI: 10.1002/lio2.259
Abstract: Acoustic analysis of voice has the potential to expedite detection and diagnosis of voice disorders. Applying an image‐based, neural‐network approach to analyzing the acoustic signal may be an effective means for detecting and differentially diagnosing… read more here.
Keywords: decoding phonation; proof concept; proof; phonation artificial ... See more keywords
Elephants, Parkinson's Disease, and Proof‐of‐Concept Clinical Trials
Sign Up to like & getrecommendations! Published in 2018 at "Movement Disorders"
DOI: 10.1002/mds.27398
Abstract: We all know the proverbial story of the committee attempting to agree on the description of an elephant. Now, more than 200 years on from James Parkinson’s codification of his now-eponymous syndrome, with his hopeful… read more here.
Keywords: elephants parkinson; disease; proof concept; proof ... See more keywords
Development and prospective in-patient proof-of-concept of a surface photogrammetry + CT-based volumetric motion model for lung radiotherapy.
Sign Up to like & getrecommendations! Published in 2019 at "Medical physics"
DOI: 10.1002/mp.13824
Abstract: PURPOSE We develop and validate a motion model that uses real-time surface photogrammetry acquired concurrently with 4DCT to estimate respiration-induced changes within the entire irradiated volume, over arbitrarily many respiratory cycles. METHODS A research, couch-mounted,… read more here.
Keywords: motion; surface; time; proof concept ... See more keywords
Hydro-jet propelled colonoscopy: proof of concept in a phantom colon
Sign Up to like & getrecommendations! Published in 2020 at "Surgical Endoscopy"
DOI: 10.1007/s00464-020-08089-z
Abstract: Background Colonoscopy is a widely used and effective procedure, but it often causes patient discomfort and its execution requires considerable skill and training. We demonstrate an alternative approach to colonoscope propulsion with the potential to… read more here.
Keywords: phantom; hydro; colonoscopy; colon ... See more keywords
Paradoxical home temperatures during cold weather: a proof-of-concept study
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Biometeorology"
DOI: 10.1007/s00484-020-01998-7
Abstract: There is substantial epidemiological evidence on the associations between cold weather and adverse health effects. Meteorological alarm systems are being developed globally, and generalized protective advice is given to the public based on outdoor exposure… read more here.
Keywords: proof concept; concept study; cold weather; controlled apartments ... See more keywords