Silk Protein Bioresorbable, Drug-Eluting Ear Tubes: Proof-of-Concept.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201801409
Abstract: Otitis media with effusion (OEM) is a common pediatric pathology treated with topical fluoroquinolones (ear drops) and tympanoplasty tube, also referred to as ear tube, implantation for middle ear drainage. Commercially available ear tubes are… read more here.
Keywords: ear tubes; drug eluting; drug; silk ... See more keywords
Plants as a cost‐effective source for customizable photosynthetic wound dressings: A proof of concept study
Sign Up to like & getrecommendations! Published in 2024 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28705
Abstract: Oxygen is essential for tissue regeneration, playing a crucial role in several processes, including cell metabolism and immune response. Therefore, the delivery of oxygen to wounds is an active field of research, and recent studies… read more here.
Keywords: tissue regeneration; concept study; oxygen; proof concept ... See more keywords
Using ex vivo bioengineered lungs to model pathologies and screening therapeutics: A proof‐of‐concept study
Sign Up to like & getrecommendations! Published in 2024 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28754
Abstract: Respiratory diseases, claim over eight million lives annually. However, the transition from preclinical to clinical phases in research studies is often hindered, partly due to inadequate representation of preclinical models in clinical trials. To address… read more here.
Keywords: pathologies screening; proof concept; using vivo; model ... See more keywords
An agile, data‐driven approach for target selection in rTMS therapy for anxiety symptoms: Proof of concept and preliminary data for two novel targets
Sign Up to like & getrecommendations! Published in 2023 at "Brain and Behavior"
DOI: 10.1002/brb3.2914
Abstract: Data‐driven approaches to transcranial magnetic stimulation (TMS) might yield more consistent and symptom‐specific results based on individualized functional connectivity analyses compared to previous traditional approaches due to more precise targeting. We provide a proof of… read more here.
Keywords: agile data; proof concept; data driven; target selection ... See more keywords
Structure of proof of concept studies that precede a nonalcoholic steatohepatitis development program
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.560
Abstract: Surrogate endpoints for clinical proof of concept (POC) trials in nonalcoholic steatohepatitis (NASH) are based upon expert pathological review of liver biopsies. During early development, these long‐term POC studies (≥48 weeks) add cost and time… read more here.
Keywords: proof concept; poc; development; nonalcoholic steatohepatitis ... See more keywords
A Machine Learning Approach for Handling Big Data Produced by High Resolution Mass Spectrometry after Data Independent Acquisition of Small Molecules - Proof of Concept Study Using an Artificial Neural Network for Sample Classification.
Sign Up to like & getrecommendations! Published in 2020 at "Drug testing and analysis"
DOI: 10.1002/dta.2775
Abstract: Liquid chromatography coupled to high-resolution mass spectrometry (HRMS) enables data independent acquisition (DIA) and untargeted screening. However, to avoid the handling of the resulting large dataset, most laboratories in that field still use targeted screening… read more here.
Keywords: machine; high resolution; machine learning; proof concept ... See more keywords
A Deep Metagenomic Snapshot as a Proof‐of‐Concept for Resource Generation: Simultaneous Assembly of Host, Food, and Microbiome Genomes From Stingless Bee Larval Food
Sign Up to like & getrecommendations! Published in 2025 at "Ecology and Evolution"
DOI: 10.1002/ece3.72546
Abstract: ABSTRACT Characterizing the complex web of ecological interactions is a central challenge in molecular ecology. Shotgun metagenomics of environmental samples offers a powerful, high‐resolution approach, yet its potential for simultaneously generating multiple genomic resources from… read more here.
Keywords: larval food; food; proof concept; ecology ... See more keywords
Nitrates in combination with hydralazine in cardiorenal syndrome: a randomized controlled proof‐of‐concept study
Sign Up to like & getrecommendations! Published in 2020 at "ESC Heart Failure"
DOI: 10.1002/ehf2.13076
Abstract: Cardiorenal syndrome (CRS) is a common problem of great morbidity and mortality. Hydralazine–isosorbide dinitrate (H‐ISDN) may be used in renal failure and may improve exercise capacity in heart failure (HF). Our proof‐of‐concept study aimed to… read more here.
Keywords: proof concept; cardiorenal syndrome; concept study;
Proof‐of‐concept evidence for trimodal simultaneous investigation of human brain function
Sign Up to like & getrecommendations! Published in 2021 at "Human Brain Mapping"
DOI: 10.1002/hbm.25541
Abstract: The link between spatial (where) and temporal (when) aspects of the neural correlates of most psychological phenomena is not clear. Elucidation of this relation, which is crucial to fully understand human brain function, requires integration… read more here.
Keywords: concept evidence; human brain; brain function; proof concept ... See more keywords
Psychological First Aid by AI: Proof‐of‐Concept and Comparative Performance of ChatGPT‐4 and Gemini in Different Disaster Scenarios
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Psychology"
DOI: 10.1002/jclp.23808
Abstract: ABSTRACT Objective This study aimed to evaluate the performance and proof‐of‐concept of psychological first aid (PFA) provided by two AI chatbots, ChatGPT‐4 and Gemini. Methods A mixed‐method cross‐sectional analysis was conducted using validated PFA scenarios… read more here.
Keywords: disaster; chatgpt; proof concept; psychological first ... See more keywords
Proof of Concept: Macro‐Raman Mapping of a Three‐Dimensional Object
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Raman Spectroscopy"
DOI: 10.1002/jrs.6786
Abstract: Macro‐Raman mapping has been proposed as a novel technique to visualise the molecular distribution over a surface of typically several tens of cm2. By combining large stages with a fibre‐optic probe head of a Raman… read more here.
Keywords: proof concept; raman mapping; macro raman; concept macro ... See more keywords