Biocatalytic synthesis of 2′‐deoxynucleotide 5′‐triphosphates from bacterial genomic DNA: Proof of principle
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28374
Abstract: 2′‐deoxynucleoside 5′‐triphosphates (dNTPs) are the building blocks of DNA and are key reagents which are incorporated by polymerase enzymes during nucleic acid amplification techniques, such as polymerase chain reaction (PCR). These techniques are of high… read more here.
Keywords: proof principle; dna; genomic dna; bacterial genomic ... See more keywords
Treatment of estrogen-dependent diseases: Design, synthesis and profiling of a selective 17β-HSD1 inhibitor with sub-nanomolar IC50 for a proof-of-principle study.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.11.004
Abstract: Current endocrine therapeutics for the estrogen-dependent disease endometriosis often lead to considerable side-effects as they act by reducing estrogen action systemically. A more recent approach takes advantage of the fact that the weak estrogen estrone… read more here.
Keywords: estrogen dependent; hsd1; estrogen; nanomolar ic50 ... See more keywords
Mercury ring pump proof-of-principle testing in the THESEUS facility
Sign Up to like & getrecommendations! Published in 2017 at "Fusion Engineering and Design"
DOI: 10.1016/j.fusengdes.2017.03.119
Abstract: Abstract For the DEMO torus vacuum system, liquid ring pumps (LRPs) with mercury as working fluid have been proposed. These vacuum pumps shall be used for pumping the torus down to a pressure The paper… read more here.
Keywords: pump; facility; proof principle; mercury ... See more keywords
Resistance training in patients with schizophrenia: Concept and proof of principle trial.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of psychiatric research"
DOI: 10.1016/j.jpsychires.2019.09.015
Abstract: Resistance training has been shown to contribute to the prevention and management of cardiovascular diseases, which is why it can help reducing morbidity and mortality in schizophrenia patients. Moreover, positive effects on different schizophrenia symptom… read more here.
Keywords: principle trial; proof principle; resistance; resistance training ... See more keywords
Proof of Principle for Local Delivery of a c-Met Inhibitor.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2017.10.025
Abstract: The reported proof of principle study demonstrated the feasibility of local delivery of a c-Met inhibitor (VXc-140) in a subcutaneous xenograft tumor model. VXc-140 was formulated in a wafer delivery system for direct implantation into… read more here.
Keywords: delivery met; delivery; vxc 140; local delivery ... See more keywords
General Metadynamics Protocol To Simulate Activation/Deactivation of Class A GPCRs: Proof of Principle for the Serotonin Receptor.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.3c00208
Abstract: We present a generally applicable metadynamics protocol for characterizing the activation free-energy profiles of class A G-protein coupled receptors and a proof-of-principle study for the 5HT1A-receptor. The almost universal A100 activation index, which depends on… read more here.
Keywords: proof principle; class; serotonin receptor; metadynamics protocol ... See more keywords
White matter hyperintensity shape and location feature analysis on brain MRI; proof of principle study in patients with diabetes
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-20084-y
Abstract: Cerebral small vessel disease is a heterogeneous disease in which various underlying etiologies can lead to different types of white matter hyperintensities (WMH). WMH shape features might aid in distinguishing these different types. In this… read more here.
Keywords: wmh; shape; study patients; principle study ... See more keywords
An in vitro proof-of-principle study of sonobactericide
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-21648-8
Abstract: Infective endocarditis (IE) is associated with high morbidity and mortality rates. The predominant bacteria causing IE is Staphylococcus aureus (S. aureus), which can bind to existing thrombi on heart valves and generate vegetations (biofilms). In… read more here.
Keywords: infected clots; vitro proof; principle study; study ... See more keywords
Microfluidic 68Ga-labeling: a proof of principle study.
Sign Up to like & getrecommendations! Published in 2018 at "Dalton transactions"
DOI: 10.1039/c8dt00158h
Abstract: Positron emission tomography (PET) as a tool for molecular imaging of cancer has gained huge interest in the last few years. Gallium-68 is a popular PET nuclide due to its favorable characteristics, like advantageous half-life… read more here.
Keywords: microfluidic 68ga; proof principle; principle study; 68ga labeling ... See more keywords
Dual-Function MR-Guided Hyperthermia: An Innovative Integrated Approach and Experimental Demonstration of Proof of Principle
Sign Up to like & getrecommendations! Published in 2021 at "IEEE Transactions on Biomedical Engineering"
DOI: 10.1109/tbme.2020.3012734
Abstract: Temperature monitoring plays a central role in improving clinical effectiveness of adjuvant hyperthermia. The potential of magnetic resonance thermometry for treatment monitoring purposes led to several MR-guided hyperthermia approaches. However, the proposed solutions were sub-optimal… read more here.
Keywords: hyperthermia; guided hyperthermia; approach; dual function ... See more keywords
Effect of pneumatic compression device and stocking use on symptoms and quality of life in women with lipedema: A proof-in-principle randomized trial
Sign Up to like & getrecommendations! Published in 2022 at "Phlebology"
DOI: 10.1177/02683555221145779
Abstract: Objective Does short-term use of pneumatic compression devices (PCD) and off-the-shelf compression alleviate symptoms and improve quality of life in women with lipedema and secondary lipolymphedema? Methods Prospective, randomized controlled, industry-sponsored, proof-in-principle study comparing PCD… read more here.
Keywords: compression; proof principle; quality life; pneumatic compression ... See more keywords