Ruxolitinib/nilotinib cotreatment inhibits leukemia-propagating cells in Philadelphia chromosome-positive ALL
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-017-1286-5
Abstract: BackgroundAs one of the major treatment obstacles in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL), relapse of Ph+ALL may result from the persistence of leukemia-propagating cells (LPCs). Research using a xenograft mouse assay recently determined that… read more here.
Keywords: propagating cells; ruxolitinib nilotinib; chromosome positive; philadelphia chromosome ... See more keywords
Gamma Irradiation Triggers Immune Escape in Glioma-Propagating Cells
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DOI: 10.3390/cancers14112728
Abstract: Simple Summary Stem cell-like glioma-propagating cells (GPCs) are crucial for initiation, growth, and treatment resistance of glioblastoma multiforme. Due to their strong immunosuppressive activities, they essentially limit immunotherapeutic approaches. This study offers a new model… read more here.
Keywords: glioma propagating; immune escape; propagating cells; irradiation ... See more keywords