Proximity-induced amino-yne reaction for selective MDM4 conjugation via propargylated sulfonium
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DOI: 10.1016/j.cclet.2021.04.015
Abstract: ABSTRACT Whilst most bioorthogonal reactions focus on targeting binding-site cysteine residues, proximity-induced reactivity effect ensures that reaction also occurs at nucleophilic lysine residues. We report one example here that the propargylated-sulfonium center undergoes a nucleophilic… read more here.
Keywords: proximity; propargylated sulfonium; amino yne; reaction ... See more keywords