Synthesis of Iodine-Substituted Quinolines, Quinolinium Salts, and Isoquinolinium Salts via a Three-Component Tandem Reaction of Aryl Azides, Propargylic Alcohols, and Iodine
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DOI: 10.1002/ajoc.201600503
Abstract: An efficient three component tandem reaction of aryl azides, propargylic alcohols and iodine has been developed. The products of the reaction hinge on the type of the propargylic alcohols: for tertiary alcohols the reaction proceeded… read more here.
Keywords: aryl azides; three component; propargylic alcohols; reaction ... See more keywords
Dihalohydration of Alkynols: A Versatile Approach to Diverse Halogenated Molecules
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DOI: 10.1002/ejoc.201800668
Abstract: In this paper we outline how dihalohydration reactions of propargylic alcohols can be used to access a wide variety of useful halogenated building blocks. A novel procedure for dibromohydration of alkynes has been developed, and… read more here.
Keywords: approach diverse; dihalohydration alkynols; alkynols versatile; versatile approach ... See more keywords
Synthesis Cu(I)–CN-based MOF with in-situ generated cyanogroup by cleavage of acetonitrile: Highly efficient for catalytic cyclization of propargylic alcohols with CO2
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Catalysis"
DOI: 10.1016/j.mcat.2020.111190
Abstract: Abstract Developing a highly effective process for synthesis a cyano-bridged compound to avoid toxic organic or inorganic cyanides is very significant method for alleviating cyanides pollution. Here, a CN-based MOF catalyst (Cu(I)–CN–BPY) was synthesized by… read more here.
Keywords: synthesis; alcohols co2; propargylic alcohols; cyclization ... See more keywords
On the phase behaviour of oxetane-CO2 and propargylic alcohols-CO2 binary mixtures by in situ infrared micro-spectrometry
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Supercritical Fluids"
DOI: 10.1016/j.supflu.2017.03.009
Abstract: Abstract The phase behaviour of carbon dioxide/propargylic alcohols and carbon dioxide/oxetanes mixtures has been investigated using in-situ FTIR microspectrometry that allows us determining the evolution of the concentration of each component in the liquid phase… read more here.
Keywords: binary mixtures; phase; behaviour oxetane; liquid phase ... See more keywords
A mild method for the replacement of a hydroxyl group by halogen: 3. the dichotomous behavior of α-haloenamines towards allylic and propargylic alcohols
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DOI: 10.1016/j.tet.2021.132148
Abstract: Abstract A study of the deoxyhalogenation of allylic and propargylic alcohols with tetramethyl-α-halo-enamines is reported. Primary allylic and primary and secondary propargylic alcohols gave the corresponding halides in high yields. Secondary allylic and propargylic alcohols… read more here.
Keywords: replacement hydroxyl; allylic propargylic; propargylic alcohols; method replacement ... See more keywords
Regioselective dehydroxytrifluoromethylthiolation of allylic and propargylic alcohols with AgSCF3
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DOI: 10.1016/j.tetlet.2019.02.045
Abstract: Abstract The reaction of easily available Morita–Baylis–Hillman (MBH) alcohols with AgSCF3 in the presence of n-Bu4NI and KI affords primary allylic SCF3 products in high yields and excellent regioselectivities. This regioselective dehydroxytrifluoromethylthiolation protocol could also… read more here.
Keywords: alcohols agscf3; allylic propargylic; propargylic alcohols; regioselective dehydroxytrifluoromethylthiolation ... See more keywords
Iodo(III)-Meyer-Schuster Rearrangement of Propargylic Alcohols Promoted by Benziodoxole Triflate.
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DOI: 10.1021/acs.orglett.1c00039
Abstract: Benziodoxole triflate (BXT), a cyclic iodine(III) electrophile, has been found to promote a rearrangement of propargylic alcohols into α,β-unsaturated ketones bearing an α-λ3-iodanyl group. This iodo(III)-Meyer-Schuster rearrangement proceeds under mild conditions and tolerates a variety… read more here.
Keywords: schuster rearrangement; meyer schuster; propargylic alcohols;
A Biocatalytic Platform for the Synthesis of Enantiopure Propargylic Alcohols and Amines
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DOI: 10.1021/acs.orglett.2c01547
Abstract: Propargylic alcohols and amines are versatile building blocks in organic synthesis. We demonstrate a straightforward enzymatic cascade to synthesize enantiomerically pure propargylic alcohols and amines from readily available racemic starting materials. In the first step,… read more here.
Keywords: synthesis enantiopure; alcohols amines; propargylic alcohols; platform synthesis ... See more keywords
Palladium-Catalyzed Arylcarboxylation of Propargylic Alcohols with CO2 and Aryl Halides: Access to Functionalized α-Alkylidene Cyclic Carbonates.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b00111
Abstract: A palladium-catalyzed, three-component reaction between propargylic alcohols, CO2, and aryl halides was developed whereby a sequential carboxylation, trans-oxopalladation of the C≡C bond by an ArPdX species, and a reductive elimination procedure afforded a series of… read more here.
Keywords: functionalized alkylidene; palladium catalyzed; propargylic alcohols; aryl halides ... See more keywords
Asymmetric SN2′-type C–H functionalization of arenes with propargylic alcohols
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DOI: 10.1039/c7qo00588a
Abstract: Herein we present the first example of transition metal-mediated stereodefined β-OH elimination, an atom economical [Cp*RhCl2]2-catalyzed SN2′-type coupling between easily available arenes and non-terminal tertiary 2-alkynylic alcohols at rt affording fully substituted allenes with H2O… read more here.
Keywords: asymmetric sn2; sn2 type; propargylic alcohols; type functionalization ... See more keywords
Gold(i)-catalyzed tandem cyclization of cyclopropylidene-tethered propargylic alcohols: an approach to functionalized naphtho[2,3-c]pyrans.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc03285a
Abstract: An unprecedented gold(i)-catalyzed cyclization of cyclopropylidene-tethered propargylic alcohols via a 6-endo-dig enyne cyclization followed by a ring-opening of cyclopropane and nucleophilic closure reaction to construct naphtho[2,3-c]pyrans was developed. This transformation represents a highly efficient method… read more here.
Keywords: cyclization cyclopropylidene; tethered propargylic; cyclization; propargylic alcohols ... See more keywords