HFIP-Empowered One-Pot Synthesis of C4-Aryl-Substituted Tetrahydroquinolines with Propargylic Chlorides and Anilines.
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DOI: 10.1021/acs.orglett.2c04299
Abstract: Transition-metal-free, practical one-pot synthesis of C4-aryl-substituted tetrahydroquinolines from simple anilines and readily accessible propargylic chlorides has been developed. Activation of the C-Cl bond by 1,1,1,3,3,3-hexafluoroisopropanol turned out to be the key interaction, which allowed C-N… read more here.
Keywords: propargylic chlorides; one pot; pot synthesis; synthesis aryl ... See more keywords