Copper-catalyzed formal propargylic [3 + 2] cycloaddition for stereoselective construction of (E)-β-pyrazolylacrylates
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DOI: 10.1016/j.tetlet.2019.151409
Abstract: Abstract A copper-catalyzed formal propargylic [3 + 2] cycloaddition between propargylic acetates and 3-(2-tosylhydrazono)propanoates for the synthesis of (E)-β-substituted-β-pyrazolylacrylates has been realized. The reaction showed broad substrate scope and excellent stereoselectivities, thus leading to a variety of… read more here.
Keywords: formal propargylic; propargylic cycloaddition; catalyzed formal; cycloaddition stereoselective ... See more keywords
Intramolecular Copper-Catalyzed Asymmetric Propargylic [4 + 2]- Cycloaddition toward Optically Active Tetrahydroisoindolo[2,1-a]quinoxalines.
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DOI: 10.1021/acs.orglett.2c02155
Abstract: An intramolecular Cu-catalyzed asymmetric propargylic [4 + 2] cycloaddition of bis-N-nucleophile-functionalized propargylic esters has been realized in the support of a chiral tridentate N-ligand, (S,S)-Pybox-diOAc, leading to chiral tetrahydroisoindolo[2,1-a]quinoxalines in high yields and with good… read more here.
Keywords: propargylic cycloaddition; asymmetric propargylic; optically active; catalyzed asymmetric ... See more keywords
Copper-Catalyzed Asymmetric Propargylic [3 + 2] Cycloaddition: Synthesis of Enantioenriched Dihydrofuro[3,2-c]coumarins and its Quinolinone and Thiocoumarin Analogues.
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DOI: 10.1021/acs.orglett.3c01198
Abstract: A copper(II)-P,N,N-ligand catalyzed propargylic [3 + 2] cycloaddition approach for the synthesis of optically enriched dihydrofuro[3,2-c]coumarins has been accomplished for the first time. The cycloaddition utilizes propargylic esters as C2-bis-electrophiles and 4-hydroxycoumarin derivatives as C,O-bis-nucleophiles.… read more here.
Keywords: propargylic cycloaddition; dihydrofuro coumarins; quinolinone thiocoumarin; coumarins quinolinone ... See more keywords