Hydrogen-Bond-Promoted Friedel–Crafts Reaction of Secondary Propargylic Fluorides: Preparation of 1-Alkyl-1-aryl-2-alkynes
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DOI: 10.1055/s-0036-1589057
Abstract: We report that aromatic propargylation is achievable with secondary propargylic fluorides, thus affording 1-alkyl-1-aryl-2-alkynes. In the present case, hydrogen bonding is responsible for the activation of the C–F bond. A large excess of arene nucleophile… read more here.
Keywords: secondary propargylic; hydrogen bond; aryl alkynes; propargylic fluorides ... See more keywords
Synthesis of Propargylic Fluorides toward Carbo- and Heterocycles with Mono- and gem-Difluorinated Side Chains
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DOI: 10.1055/s-0036-1589484
Abstract: This review reports the synthesis of propargylic derivatives with alkyl chains bearing either one fluorine or a gem -difluoro system. The preparation of the different categories of fluorinated derivatives is analyzed in a systematic manner,… read more here.
Keywords: synthesis propargylic; side chains; gem; carbo heterocycles ... See more keywords