Synthesis of Sulfur-Substituted Bicyclo[1.1.1]pentanes by Iodo-Sulfenylation of [1.1.1]Propellane
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DOI: 10.1021/acs.orglett.2c02875
Abstract: Thiols easily react with [1.1.1]propellane to give sulfur-substituted bicyclo[1.1.1]pentanes in radical reactions, but this reactivity is not replicated in the case of heterocyclic thiols. Herein, we address this issue by electrophilically activating [1.1.1]propellane to promote… read more here.
Keywords: bicyclo pentanes; iodo sulfenylation; sulfur substituted; substituted bicyclo ... See more keywords
Radical-mediated sulfonyl alkynylation, allylation, and cyanation of propellane.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc02249k
Abstract: Bicyclo[1.1.1]pentane (BCP) is widely applied as the bioisostere for aryl, internal alkynes, and tert-butyl groups in medicinal chemistry. We herein disclose an efficient and practical preparation of sulfonyl alkynyl/allyl/cyano-substituted BCP derivatives through a novel radical-mediated… read more here.
Keywords: alkynylation allylation; allylation cyanation; propellane; radical mediated ... See more keywords
Synthesis of Nitro- and Acetyl Derivatives of 3,7,10-Trioxo-2,4,6,8,9,11-hexaaza[3.3.3]propellane
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DOI: 10.3390/ma15238320
Abstract: Here, we report the study results of the nitration of 3,7,10-trioxo-2,4,6,8,9,11-hexaaza[3.3.3]propellane (THAP) by different nitrating agents such as nitric acid, mixed nitric/sulfuric acids, nitric anhydride, and mixed concentrated nitric acid/acetic anhydride to furnish 3,7,10-trioxo-2-nitro-2,4,6,8,9,11-hexaaza[3.3.3]propellane and… read more here.
Keywords: acetyl derivatives; synthesis nitro; trioxo hexaaza; hexaaza propellane ... See more keywords