Radical Acylation of [1.1.1]Propellane with Aldehydes: Synthesis of Bicyclo[1.1.1]pentane Ketones.
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DOI: 10.1021/acs.orglett.2c01707
Abstract: Bicyclo[1.1.1]pentanes (BCPs) are widely utilized in drug design as sp3-rich bioisosteres for tert-butyl, internal alkynes, and aryl groups. A general and mild method for radical acylation of [1.1.1]propellane with aldehydes has been developed. The protocol… read more here.
Keywords: acylation propellane; propellane aldehydes; bicyclo pentane; pentane ketones ... See more keywords