Initial properdin binding contributes to alternative pathway activation at the surface of viable and necrotic cells
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149259
Abstract: Properdin, the only known positive regulator of the complement system, stabilizes the C3 convertase, thereby increasing its halfâlife. In contrast to most other complement factors, properdin is mainly produced extrahepatically by myeloid cells. Recent data… read more here.
Keywords: properdin binding; alternative pathway; necrotic cells; properdin ... See more keywords
Structural studies offer a framework for understanding the role of properdin in the alternative pathway and beyond
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DOI: 10.1111/imr.13129
Abstract: Structures of alternative pathway proteins have offered a comprehensive structural basis for understanding the molecular mechanisms governing activation and regulation of the amplification pathway of the complement cascade. Although properdin (FP) is required in vivo… read more here.
Keywords: structural studies; studies offer; offer framework; alternative pathway ... See more keywords
Urinary Properdin and sC5b-9 Are Independently Associated With Increased Risk for Graft Failure in Renal Transplant Recipients
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DOI: 10.3389/fimmu.2019.02511
Abstract: The pathophysiology of late kidney-allograft failure remains complex and poorly understood. Activation of filtered or locally produced complement may contribute to the progression of renal failure through tubular C5b-9 formation. This study aimed to determine… read more here.
Keywords: urinary properdin; sc5b; graft failure; properdin sc5b ... See more keywords
Prognostic Value of Complement Properdin in Cancer
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DOI: 10.3389/fimmu.2020.614980
Abstract: The complement system is readily triggered by the presence of damage-associated molecular patterns on the surface of tumor cells. The complement alternative pathway provides rapid amplification of the molecular stress signal, leading to complement cascade… read more here.
Keywords: prognostic value; analysis; complement; dendritic cells ... See more keywords
Complement Properdin Regulates the Metabolo-Inflammatory Response to a High Fat Diet
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DOI: 10.3390/medicina56090484
Abstract: Background and objectives: Overnutrition leads to a metabolic and inflammatory response that includes the activation of Complement. Properdin is the only amplifier of complement activation and increases the provision of complement activation products. Its absence… read more here.
Keywords: hfd; fat diet; high fat; properdin ... See more keywords