Synthesis and hybridization properties of oligonucleotide analogues with novel acyclic triazole internucleotide linkages.
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DOI: 10.1016/j.bioorg.2017.04.004
Abstract: Herein, we describe synthesis of novel acyclic dinucleotide analogues connected via triazole linkage in CuAAC reaction. Synthesis pathway starting from previously obtained building blocks containing alkyne or azide functional group is described. Further functionalization and… read more here.
Keywords: novel acyclic; oligonucleotide analogues; properties oligonucleotide; hybridization properties ... See more keywords