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Two mechanisms repress cyclin B1 translation to maintain prophase arrest in mouse oocytes

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0 Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-54161-w

Abstract: In mammals, oocytes are arrested in prophase of meiosis I for long periods of time. Prophase arrest is critical for reproduction because it allows oocytes to grow to their full size to support meiotic maturation… read more here.

Keywords: prophase arrest; two mechanisms; prophase; cyclin translation ... See more keywords

Translational repression by 4E-T is crucial to maintain the prophase-I arrest in vertebrate oocytes

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0 Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-62971-9

Abstract: Meiotic maturation of vertebrate oocytes occurs in the near-absence of transcription. Thus, female fertility relies on timely translational activation of maternal transcripts stockpiled in full-grown prophase-I-arrested oocytes. However, how expression of these mRNAs is suppressed… read more here.

Keywords: prophase; prophase arrest; repression; maintain prophase ... See more keywords

WIP1 phosphatase suppresses the DNA damage response during G2/prophase arrest in mouse oocytes†

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1 Published in 2018 at "Biology of Reproduction"

DOI: 10.1093/biolre/ioy108

Abstract: Abstract Maternal DNA damage duringmeiosis causes genetic abnormalities that can lead to infertility, birth defects, and abortion. While DNA damage can rapidly halt cell cycle progression and promote DNA repair in somatic cells, mammalian oocytes… read more here.

Keywords: prophase arrest; dna damage; damage;