Limited-stage small cell lung cancer: Outcomes associated with prophylactic cranial irradiation over a 20-year period at the Princess Margaret Cancer Centre
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Translational Radiation Oncology"
DOI: 10.1016/j.ctro.2021.06.009
Abstract: Highlights • Prophylactic cranial irradiation (PCI) was more commonly used in younger patients.• PCI utilization rates did not change throughout our 20-year institutional experience.• PCI was associated with improved OS and lower brain metastasis risk,… read more here.
Keywords: limited stage; year; prophylactic cranial; cranial irradiation ... See more keywords
Prophylactic Cranial Irradiation or No Prophylactic Cranial Irradiation after Adjuvant Chemotherapy in Resected Small Cell Lung Cancer
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Thoracic Oncology"
DOI: 10.1016/j.jtho.2016.12.002
Abstract: http://dx.doi.org/10.1016/j.jtho.2016.12.002 In the literature, there are limited data on thoracic surgery in patients with SCLC and even more scarce data on prophylactic cranial irradiation (PCI) in these same patients. The main reason is that because… read more here.
Keywords: stage; prophylactic cranial; cranial irradiation; adjuvant chemotherapy ... See more keywords
Randomized Phase II Study Comparing Prophylactic Cranial Irradiation Alone to Prophylactic Cranial Irradiation and Consolidative Extracranial Irradiation for Extensive‐Disease Small Cell Lung Cancer (ED SCLC): NRG Oncology RTOG 0937
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Thoracic Oncology"
DOI: 10.1016/j.jtho.2017.06.015
Abstract: Introduction: NRG Oncology RTOG 0937 is a randomized phase II trial evaluating 1‐year overall survival (OS) with prophylactic cranial irradiation (PCI) or PCI plus consolidative radiation therapy (PCI+cRT) to intrathoracic disease and extracranial metastases for… read more here.
Keywords: pci crt; prophylactic cranial; oncology; cranial irradiation ... See more keywords
Role of prophylactic cranial irradiation for elderly patients with limited-disease small-cell lung cancer: inverse probability of treatment weighting using propensity score
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Radiation Research"
DOI: 10.1093/jrr/rrz040
Abstract: Abstract Studies of prophylactic cranial irradiation (PCI) focused on elderly patients with small-cell lung cancer (SCLC) are rarely conducted. We aimed to identify whether there is a survival benefit of prophylactic cranial irradiation (PCI) in… read more here.
Keywords: prophylactic cranial; disease; elderly patients; cranial irradiation ... See more keywords
Prophylactic cranial irradiation in small cell lung cancer: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2018 at "BMC Cancer"
DOI: 10.1186/s12885-018-5251-3
Abstract: BackgroundThe efficacy of prophylactic cranial irradiation (PCI) in treating patients with small cell lung cancer (SCLC) has not been clear, and recent randomized studies have demonstrated conflicting results from previously published findings. The purpose of… read more here.
Keywords: analysis; prophylactic cranial; cranial irradiation; cancer ... See more keywords
Randomized Phase III Trial of Prophylactic Cranial Irradiation With or Without Hippocampal Avoidance for Small-Cell Lung Cancer (PREMER): A GICOR-GOECP-SEOR Study
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.21.00639
Abstract: PURPOSE Radiation dose received by the neural stem cells of the hippocampus during whole-brain radiotherapy has been associated with neurocognitive decline. The key concern using hippocampal avoidance-prophylactic cranial irradiation (HA-PCI) in patients with small-cell lung… read more here.
Keywords: hippocampal avoidance; brain; cranial irradiation; prophylactic cranial ... See more keywords
Prophylactic Cranial Irradiation for Extensive Small-Cell Lung Cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of oncology practice"
DOI: 10.1200/jop.2017.026765
Abstract: Small-cell lung cancer (SCLC) has a high predilection for metastasizing to the brain after chemotherapy. This has been blamed on the blood-brain barrier, which prevents chemotherapy from penetrating into the brain, thus creating a sanctuary… read more here.
Keywords: brain metastases; prophylactic cranial; cell lung; lung cancer ... See more keywords
Prophylactic Cranial Irradiation for Extensive-Stage Small-Cell Lung Cancer: A Controversial Area
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.772282
Abstract: Small-cell lung cancer (SCLC) is a highly aggressive malignant tumor that is prone to lead to the development of brain metastases (BM). The application of prophylactic cranial irradiation (PCI) has been regarded as an important… read more here.
Keywords: lung cancer; prophylactic cranial; small cell; stage ... See more keywords
Benefits of Prophylactic Cranial Irradiation in the MRI Era for Patients With Limited Stage Small Cell Lung Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.833478
Abstract: Purpose Previous studies have shown that prophylactic cranial irradiation (PCI) can improve the survival of patients with limited-stage small cell lung cancer (LS-SCLC). PCI is recommended for patients who respond well to chemoradiotherapy. However, whether… read more here.
Keywords: cancer; pci; mri; era ... See more keywords
Volumetric modulated arc therapy for hippocampal-sparing prophylactic cranial irradiation: Planning comparison of Halcyon and C-arm accelerators
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.993809
Abstract: Background The purpose of the study was to evaluate the dosimetry of the Halcyon in prophylactic cranial irradiation (PCI) with volumetric modulated arc therapy (VMAT) and hippocampal-sparing for small cell lung cancer (SCLC). Methods Five… read more here.
Keywords: hippocampal sparing; cranial irradiation; prophylactic cranial; halcyon ... See more keywords
The value of prophylactic cranial irradiation in limited-stage small cell lung cancer: should it always be recommended?
Sign Up to like & getrecommendations! Published in 2019 at "Radiation Oncology Journal"
DOI: 10.3857/roj.2019.00318
Abstract: Purpose Prophylactic cranial irradiation (PCI) is a standard treatment for limited-stage small cell lung cancer (LS-SCLC) showing a response to initial treatment, but many patients do not receive PCI due to comorbidities or refusal. This… read more here.
Keywords: limited stage; stage small; prophylactic cranial; cranial irradiation ... See more keywords