Inactivation of SARS-CoV-2 by β-propiolactone causes aggregation of viral particles and loss of antigenic potential
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DOI: 10.1016/j.virusres.2021.198555
Abstract: Inactivated viral preparations are important resources in vaccine and antisera industry. Of the many vaccines that are being developed against COVID-19, inactivated whole-virus vaccines are also considered effective. β-propiolactone (BPL) is a widely used chemical… read more here.
Keywords: antigenic potential; propiolactone; loss antigenic; inactivation ... See more keywords
Synthesis and Biodegradation of Poly(l-lactide-co-β-propiolactone)
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DOI: 10.3390/ijms18061312
Abstract: Although the copolymerizations of l-lactide (LA) with seven- or six-membered ring lactones have been extensively studied, the copolymerizations of LA with four-membered ring lactones have scarcely been reported. In this work, we studied the copolymerization… read more here.
Keywords: propiolactone; biodegradation; lactide propiolactone; poly lactide ... See more keywords
Structural and Immunoreactivity Properties of the SARS-CoV-2 Spike Protein upon the Development of an Inactivated Vaccine
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DOI: 10.3390/v15020480
Abstract: Inactivated vaccines are promising tools for tackling the COVID-19 pandemic. We applied several protocols for SARS-CoV-2 inactivation (by β-propiolactone, formaldehyde, and UV radiation) and examined the morphology of viral spikes, protein composition of the preparations,… read more here.
Keywords: propiolactone; properties sars; immunoreactivity properties; immunoreactivity ... See more keywords