13C-assisted metabolomics analysis reveals the positive correlation between specific erythromycin production rate and intracellular propionyl-CoA pool size in Saccharopolyspora erythraea
Sign Up to like & getrecommendations! Published in 2017 at "Bioprocess and Biosystems Engineering"
DOI: 10.1007/s00449-017-1792-0
Abstract: Metabolomics analysis is extremely essential to explore the metabolism characteristics of Saccharopolyspora erythraea. The lack of suitable methods for the determination of intracellular metabolites, however, hinders the application of metabolomics analysis for S. erythraea. Acyl-CoAs… read more here.
Keywords: pool; metabolomics analysis; propionyl coa; erythromycin production ... See more keywords
Directed Evolution of Propionyl-CoA Carboxylase for Succinate Biosynthesis.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in biotechnology"
DOI: 10.1016/j.tibtech.2021.02.006
Abstract: Due to low carboxylase activity, CO2 biotransformation is challenging to achieve using natural CO2 fixation pathways. Liu et al. have improved the activity of propionyl-CoA carboxylase (PCC) 94-fold, enabling the efficient synthesis of succinate from… read more here.
Keywords: carboxylase; propionyl coa; coa; directed evolution ... See more keywords
Engineering propionyl-CoA pools for de novo biosynthesis of odd-chain fatty acids in microbial cell factories.
Sign Up to like & getrecommendations! Published in 2022 at "Critical reviews in biotechnology"
DOI: 10.1080/07388551.2022.2100736
Abstract: Odd-chain fatty acids (OcFAs) and their derivatives have attracted great interest due to their wide applications in the food, pharmaceutical and petrochemical industries. Microorganisms can naturally de novo produce fatty acids (FAs), where mainly, even-chain… read more here.
Keywords: propionyl coa; fatty acids; odd chain; coa ... See more keywords
Metabolic rerouting of valine and isoleucine oxidation increases survival in zebrafish models of disorders of propionyl-CoA metabolism.
Sign Up to like & getrecommendations! Published in 2025 at "Human molecular genetics"
DOI: 10.1093/hmg/ddaf100
Abstract: Branched-chain amino acid (BCAA) oxidation is a multistep process leading to the formation of acetyl-CoA and propionyl-CoA. The syndromes associated with disturbed BCAA oxidation are clinically and biochemically heterogenous. While the common organic acidemias, propionic… read more here.
Keywords: isoleucine oxidation; mmut; propionyl coa; valine isoleucine ... See more keywords
TetR Family Transcriptional Regulator PccD Negatively Controls Propionyl Coenzyme A Assimilation in Saccharopolyspora erythraea
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bacteriology"
DOI: 10.1128/jb.00281-17
Abstract: ABSTRACT Propanol stimulates erythromycin biosynthesis by increasing the supply of propionyl coenzyme A (propionyl-CoA), a starter unit of erythromycin production in Saccharopolyspora erythraea. Propionyl-CoA is assimilated via propionyl-CoA carboxylase to methylmalonyl-CoA, an extender unit of… read more here.
Keywords: pccd; propionyl coa; coa; strain ... See more keywords
Coordinated regulation of propionyl-CoA carboxylase subunits drives precursor flux optimization in spinosad production
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2025.1643527
Abstract: Spinosad, a natural agricultural pesticide produced by Saccharopolyspora spinosa, has gained global attention owing to its potent insecticidal properties and environmental compatibility. To enhance spinosad biosynthesis, the propionyl-CoA carboxylase (PCC) complex responsible for precursor synthesis… read more here.
Keywords: spinosad production; coa carboxylase; production; propionyl coa ... See more keywords