The Role of 5-HT on Proplatelet Formation and Thrombopoietin Production
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DOI: 10.1182/blood-2020-140183
Abstract: Background: Our previous work confirmed that serotonin (5-HT) promotes the proliferation of hemopoietic stem cells and megakaryocytes (Yang M et al, Stem Cells, 2007; 2014). However, the mechanisms remain indefinite. Methods: Q-PCR, Flow Cytometry, Western… read more here.
Keywords: group; effect; tpo; proplatelet formation ... See more keywords
Deletion of Grin1 in mouse megakaryocytes reveals NMDA receptor role in platelet function and proplatelet formation.
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DOI: 10.1182/blood.2021014000
Abstract: The process of proplatelet formation (PPF) requires coordinated interaction between megakaryocytes (MKs) and the extracellular matrix (ECM), followed by a dynamic reorganization of the actin and microtubule cytoskeleton. Localized fluxes of intracellular calcium ions (Ca2+)… read more here.
Keywords: platelet function; function; platelet; proplatelet formation ... See more keywords
The “Feedback” Regulation of Thrombopoiesis: The Role of Serotonin on Proplatelet Formation and TPO Production
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DOI: 10.1182/blood.v130.suppl_1.4949.4949
Abstract: We previously reported that serotonin (5-HT) is a growth factor for hematopoietic stem cells and megakaryocytic cells (Yang & Ye et al, Stem Cells, 2007; 2014). This study further proposed a possible role of serotonin… read more here.
Keywords: production; group; formation; tpo ... See more keywords
Megakaryocyte buds are distinct from microvesicles and likely to represent platelet precursors
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DOI: 10.1182/bloodadvances.2022008850
Abstract: The mechanisms responsible for platelet generation have been debated for more than a century. It is generally assumed that the physiological release of platelets from megakaryocytes (MKs) occurs pri-marily by the release of platelet-sized swellings… read more here.
Keywords: buds distinct; proplatelet formation; megakaryocyte buds; membrane structures ... See more keywords