RTA‐408 protects against propofol‐induced cognitive impairment in neonatal mice via the activation of Nrf2 and the inhibition of NF‐κB p65 nuclear translocation
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DOI: 10.1002/brb3.1918
Abstract: To explore the effect of RTA‐408 on the propofol‐induced cognitive impairment of neonatal mice via regulating Nrf2 and NF‐κB p65 nuclear translocation. read more here.
Keywords: rta 408; propofol induced; induced cognitive; cognitive impairment ... See more keywords
Highly connected and highly variable: A Core brain network during resting state supports Propofol‐induced unconsciousness
Sign Up to like & getrecommendations! Published in 2022 at "Human Brain Mapping"
DOI: 10.1002/hbm.26103
Abstract: Leading theories of consciousness make diverging predictions for where and how neural activity gives rise to subjective experience. The Global Neuronal Workspace theory (GNW) states that consciousness is instantiated through global broadcasting of information across… read more here.
Keywords: network; state; brain; propofol induced ... See more keywords
The Role of Pink1-Mediated Mitochondrial Pathway in Propofol-Induced Developmental Neurotoxicity.
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DOI: 10.1007/s11064-021-03359-1
Abstract: The mechanisms underlying propofol-induced toxicity in developing neurons are still unclear. The aim of present study was to explore the role of Pink1 mediated mitochondria pathway in propofol-induced developmental neurotoxicity. The primary Neural Stem Cells… read more here.
Keywords: propofol induced; pink1; pathway propofol; role pink1 ... See more keywords
Propofol-induced sleep ameliorates cognition impairment in sleep-deprived rats
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DOI: 10.1007/s11325-022-02591-5
Abstract: Propofol has been shown to clear sleep debt in rats after sleep deprivation (SD). We examined whether or not propofol-assisted sleep can restore cognitive function in SD rats and explored the possible mechanisms. A sleep… read more here.
Keywords: sleep deprivation; propofol induced; rats propofol; sleep ... See more keywords
TNF-α Mediates the Intrinsic and Extrinsic Pathway in Propofol-Induced Neuronal Apoptosis Via PI3K/Akt Signaling Pathway in Rat Prefrontal Cortical Neurons
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DOI: 10.1007/s12640-017-9751-8
Abstract: Propofol can cause developing neuronal apoptosis in both in vivo and in vitro studies, and the mechanism is unclear till now. Our previous study has demonstrated that propofol can increase the TNF-α expression in the… read more here.
Keywords: induced neuronal; tnf; propofol induced; apoptosis ... See more keywords
The Protective Effects of Benzbromarone Against Propofol-Induced Inflammation and Injury in Human Brain Microvascular Endothelial Cells (HBMVECs).
Sign Up to like & getrecommendations! Published in 2021 at "Neurotoxicity research"
DOI: 10.1007/s12640-021-00387-1
Abstract: It has been widely reported that severe neurotoxicity can be induced by the application of propofol, which is closely related to the disruption of the blood-brain barrier (BBB) induced by inflammation and injury in the… read more here.
Keywords: propofol; propofol induced; induced inflammation; brain ... See more keywords
S126. A study on the electrophysiological mechanism of human hippocampus in propofol-induced amnesia: An ECoG study
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Neurophysiology"
DOI: 10.1016/j.clinph.2018.04.486
Abstract: Introduction General anesthesia is known to be a drug-induces, reversible condition that includes specific behavioral and physiological traits, such as unconsciousness, amnesia, analgesia, and akinesia (Brown et al., 2010). Among those characteristic features, the underlying… read more here.
Keywords: state; propofol; hippocampal formation; propofol induced ... See more keywords
Propofol facilitates climbing fiber-Purkinje cell synaptic transmission via NMDA receptor in vitro in mice.
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DOI: 10.1016/j.ejphar.2020.173474
Abstract: Propofol is generally used for the induction and maintenance of anesthesia in clinical procedures via activation of γ -aminobutyric acid A (GABAA) receptors. When administered at the clinical dose, propofol use is associated with movement… read more here.
Keywords: propofol; propofol induced; synaptic transmission; cell ... See more keywords
Validation and bioinformatic analysis of propofol-induced differentially expressed microRNAs in primary cultured neural stem cells.
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DOI: 10.1016/j.gene.2018.04.046
Abstract: Propofol, a widely used intravenous anesthetic, was previously considered as a neuroprotective agent. Recently, however, accumulating evidence suggests that it may cause neurotoxicity, especially in the development of neural stem cells (NSCs). The potential mechanisms… read more here.
Keywords: propofol; propofol induced; mir; differentially expressed ... See more keywords
Dexmedetomidine improves propofol-induced neuronal injury in rat hippocampus with the involvement of miR-34a and the PI3K/Akt signaling pathway.
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DOI: 10.1016/j.lfs.2020.117359
Abstract: AIMS Dexmedetomidine (DEX) is a selective agonist of α2-adrenergic receptors with anesthetic attributes and neuroprotective effects. This study was designed to explore the mechanisms of DEX in the propofol-induced neuronal injury in rat hippocampus. MATERIALS… read more here.
Keywords: dex; propofol induced; mir 34a; neuronal injury ... See more keywords
miR-455-3p alleviates propofol-induced neurotoxicity by reducing EphA4 expression in developing neurons
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DOI: 10.1080/1354750x.2020.1832147
Abstract: Abstract Purpose Propofol, an aesthetic agent in paediatric patients, results in neurotoxicity in the developing neurons. To reduce side effects of propofol, the protective role of miR-455-3p (microRNA-455-3p) in developing rat brain was investigated. Materials… read more here.
Keywords: expression; developing neurons; propofol induced; cell ... See more keywords