Propofol inhibits tumor angiogenesis through targeting VEGF/VEGFR and mTOR/eIF4E signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.03.094
Abstract: Propofol, a commonly used intravenous anesthetic in tumor surgery, has recently garnered attention for its anti-cancer activity. We previously demonstrated that propofol inhibits migration and invasion of esophageal squamous cell carcinoma cells. However, the effects… read more here.
Keywords: endothelial cells; mtor eif4e; propofol inhibits; tumor angiogenesis ... See more keywords
Propofol Inhibits Biological Function of Hepatocellular Carcinoma Cells through LINC00475-Mediated Sonic Hedgehog Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacology"
DOI: 10.1159/000527200
Abstract: Introduction: Hepatocellular carcinoma (HCC) is the most deadly cancer. Many signal pathways are implicated in HCC development, including sonic hedgehog (SHH). Propofol is an anesthetic commonly used in surgery. Recent studies have reported that propofol… read more here.
Keywords: hepatocellular carcinoma; shh; hcc; propofol ... See more keywords