Impact of clinical factors and UGT1A9 and CYP2B6 genotype on inter-individual differences in propofol pharmacokinetics
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DOI: 10.1007/s00540-018-2470-3
Abstract: PurposePropofol is one of the most widely used fast-acting intravenously administered anesthetics. However, although large inter-individual differences in dose requirements and recovery time have been observed, there are few previous studies in which the association… read more here.
Keywords: individual differences; analysis; clinical factors; propofol pharmacokinetics ... See more keywords
Clinical Importance of Potential Genetic Determinants Affecting Propofol Pharmacokinetics and Pharmacodynamics
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DOI: 10.3389/fmed.2022.809393
Abstract: Interindividual variability in response to drugs used in anesthesia has long been considered the rule, not the exception. It is important to mention that in anesthesiology, the variability in response to drugs is multifactorial, i.e.,… read more here.
Keywords: pharmacokinetics pharmacodynamics; medicine; clinical importance; importance potential ... See more keywords