Targeting proprotein convertases in furin‐rich lung cancer cells results in decreased in vitro and in vivo growth
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22550
Abstract: Proprotein convertases (PCs) are serine proteases with an active role in the post‐translational processing of numerous inactive proteins to active proteins including many substrates of paramount importance in cancer development and progression. Furin (PCSKC3), a… read more here.
Keywords: convertases furin; targeting proprotein; proprotein convertases; cancer ... See more keywords
Proprotein convertases: Key players in inflammation-related malignancies and metastasis
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Letters"
DOI: 10.1016/j.canlet.2019.12.027
Abstract: Abstract Many cancers occur from locations of inflammation due to chronic irritation and/or infection. Tumor microenvironment contains various different inflammatory cells and mediators that orchestrate diverse neoplastic processes, including proliferation, survival, adhesion and migration. In… read more here.
Keywords: key players; convertases key; inflammatory cells; proprotein convertases ... See more keywords
The Role of Proprotein Convertases in Upper Airway Remodeling
Sign Up to like & getrecommendations! Published in 2022 at "Molecules and Cells"
DOI: 10.14348/molcells.2022.0019
Abstract: Chronic rhinosinusitis (CRS) is a multifactorial, heterogeneous disease characterized by persistent inflammation of the sinonasal mucosa and tissue remodeling, which can include basal/progenitor cell hyperplasia, goblet cell hyperplasia, squamous cell metaplasia, loss or dysfunction of… read more here.
Keywords: cell; proprotein convertases; tissue remodeling; role proprotein ... See more keywords
Proprotein Convertases and the Complement System
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.958121
Abstract: Proteins destined for secretion - after removal of the signal sequence - often undergo further proteolytic processing by proprotein convertases (PCs). Prohormones are typically processed in the regulated secretory pathway, while most plasma proteins travel… read more here.
Keywords: processing; complement; proprotein convertases; convertases complement ... See more keywords
Testicular Germ Cell Tumours and Proprotein Convertases
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14071633
Abstract: Simple Summary Despite the high survival rate of the most common neoplasia in young Caucasian men: Testicular Germ Cell Tumors (TGCT), the quality of life of these patients is impaired by the multiple long-term side… read more here.
Keywords: germ cell; cell tumours; testicular germ; proprotein convertases ... See more keywords
The Proteolytic Regulation of Virus Cell Entry by Furin and Other Proprotein Convertases
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DOI: 10.3390/v11090837
Abstract: A wide variety of viruses exploit furin and other proprotein convertases (PCs) of the constitutive protein secretion pathway in order to regulate their cell entry mechanism and infectivity. Surface proteins of enveloped, as well as… read more here.
Keywords: proprotein convertases; cell entry; furin proprotein; entry ... See more keywords