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   Articles with "propylthiouracil" as a keyword



Aplastic anemia secondary to propylthiouracil: A rare and life-threatening adverse effect

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recommendations! Published in 2019 at "Journal of Oncology Pharmacy Practice"

DOI: 10.1177/1078155217752079

Abstract: Background Propylthiouracil has been in use for more than half a century for the treatment of hyperthyroidism. While it is largely known to cause agranulocytosis, its association with aplastic anemia is rarely heard of. Our… read more here.

Keywords: secondary propylthiouracil; aplastic anemia; propylthiouracil rare; propylthiouracil ... See more keywords

A disproportionality analysis of FDA adverse event reporting system (FAERS) events for methimazole and propylthiouracil

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recommendations! Published in 2025 at "PLOS One"

DOI: 10.1371/journal.pone.0328889

Abstract: Background Methimazole and propylthiouracil are the most common antithyroid drugs. We assessed the safety signals associated with methimazole and propylthiouracil by data mining the FDA pharmacovigilance database. Methods Data were retrieved from the FAERS database… read more here.

Keywords: methimazole propylthiouracil; adverse events; reporting; analysis ... See more keywords

Predictive performance and verification of physiologically based pharmacokinetic model of propylthiouracil

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recommendations! Published in 2022 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2022.1013432

Abstract: Background: Propylthiouracil (PTU) treats hyperthyroidism and thyroid crisis in all age groups. A variety of serious adverse effects can occur during clinical use and require attention to its pharmacokinetic and pharmacodynamic characteristics in various populations.… read more here.

Keywords: predictive performance; pbpk model; based pharmacokinetic; propylthiouracil ... See more keywords

Propylthiouracil‐induced vasculitis in carbimazole‐refractory Graves disease

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recommendations! Published in 2019 at "Medical Journal of Australia"

DOI: 10.5694/mja2.50198

Abstract: A 59yearold woman with carbimazolerefractory Graves disease presented with fever and extensive necrotising rash (Figure) 2 weeks after commencing propylthiouracil therapy. Investigations revealed undetectable thyroidstimulating hormone (< 0.004 mIU/L; reference interval [RI], 0.400–5.00 mIU/L), elevated… read more here.

Keywords: vasculitis carbimazole; propylthiouracil; induced vasculitis; pmol pmol ... See more keywords