Aplastic anemia secondary to propylthiouracil: A rare and life-threatening adverse effect
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Oncology Pharmacy Practice"
DOI: 10.1177/1078155217752079
Abstract: Background Propylthiouracil has been in use for more than half a century for the treatment of hyperthyroidism. While it is largely known to cause agranulocytosis, its association with aplastic anemia is rarely heard of. Our… read more here.
Keywords: secondary propylthiouracil; aplastic anemia; propylthiouracil rare; propylthiouracil ... See more keywords
Predictive performance and verification of physiologically based pharmacokinetic model of propylthiouracil
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DOI: 10.3389/fphar.2022.1013432
Abstract: Background: Propylthiouracil (PTU) treats hyperthyroidism and thyroid crisis in all age groups. A variety of serious adverse effects can occur during clinical use and require attention to its pharmacokinetic and pharmacodynamic characteristics in various populations.… read more here.
Keywords: predictive performance; pbpk model; based pharmacokinetic; propylthiouracil ... See more keywords
Propylthiouracil‐induced vasculitis in carbimazole‐refractory Graves disease
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DOI: 10.5694/mja2.50198
Abstract: A 59yearold woman with carbimazolerefractory Graves disease presented with fever and extensive necrotising rash (Figure) 2 weeks after commencing propylthiouracil therapy. Investigations revealed undetectable thyroidstimulating hormone (< 0.004 mIU/L; reference interval [RI], 0.400–5.00 mIU/L), elevated… read more here.
Keywords: vasculitis carbimazole; propylthiouracil; induced vasculitis; pmol pmol ... See more keywords