Circulating prorenin: its molecular forms and plasma concentrations
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DOI: 10.1038/s41440-020-00610-0
Abstract: The renin-angiotensin-aldosterone system plays pivotal roles in the maintenance of fluid homeostasis and in the pathophysiology of major human diseases. However, the molecular forms of plasma renin/prorenin have not been fully elucidated, and measurements of… read more here.
Keywords: circulating prorenin; molecular forms; plasma prorenin; prorenin ... See more keywords
Do prorenin-synthesizing cells release active, ‘open’ prorenin?
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DOI: 10.1097/hjh.0000000000001174
Abstract: Background: The function of prorenin, the inactive precursor of renin, remains unclear after many decades of research. The discovery of a (pro)renin receptor suggested that prorenin, by binding to this receptor, would become active, that… read more here.
Keywords: open prorenin; prorenin synthesizing; cells release; synthesizing cells ... See more keywords
Abstract MP45: Prorenin Induces Intracellular Signaling And Reactive Oxygen Species In The Brainstem
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DOI: 10.1161/hyp.76.suppl_1.mp45
Abstract: The activation of the brain renin angiotensin system (RAS) is required for the blood pressure (BP) elevation in models of neurogenic hypertension (HT). However, it remains unclear whether the expression of prorenin and its binding… read more here.
Keywords: reactive oxygen; oxygen species; prorenin induces; prr ... See more keywords
S1P (Site-1 Protease)-Induced Release of the Soluble Prorenin Receptor in Hypertension: Do All Roads Lead to Ang II (Angiotensin II)?
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DOI: 10.1161/hypertensionaha.120.16428
Abstract: Since the initial discovery of a pressor activity in kidney homogenates to its isolation and identification almost 100 years later, the protease renin constitutes a critical step in the activation of the reninangiotensin system (RAS)… read more here.
Keywords: prorenin receptor; receptor; ang angiotensin; protease ... See more keywords
Effect of prorenin peptide vaccine on the early phase of diabetic retinopathy in a murine model of type 2 diabetes
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DOI: 10.1371/journal.pone.0262568
Abstract: Prorenin is viewed as an ideal target molecule in the prevention of diabetic retinopathy. However, no drugs are available for inhibiting activation of prorenin. Here, we tested the effect of a prorenin peptide vaccine (VP)… read more here.
Keywords: effect prorenin; klh; peptide vaccine; prorenin peptide ... See more keywords