PROS1 variant in sudden death case of pulmonary embolism caused by calcification in the inferior vena cava: The importance of postmortem genetic analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Legal medicine"
DOI: 10.1016/j.legalmed.2022.102029
Abstract: A Japanese man in his 30s died suddenly. Postmortem computed tomography and autopsy revealed a pulmonary embolism from an organizing thrombus in the inferior vena cava as the cause of death. Genomic analysis of congenital… read more here.
Keywords: analysis; genetic analysis; pulmonary embolism; death ... See more keywords
Recurrent pulmonary embolism associated with deep venous thrombosis diagnosed as protein s deficiency owing to a novel mutation in PROS1
Sign Up to like & getrecommendations! Published in 2018 at "Medicine"
DOI: 10.1097/md.0000000000010714
Abstract: Rationale: Protein S (PS) deficiency that can be inherited or acquired is an independent risk factor for venous thromboembolism (VTE). Patient concerns: In this report, we present a case of recurrent pulmonary embolism (PE) and… read more here.
Keywords: pros1; thrombosis; protein deficiency; recurrent pulmonary ... See more keywords
Protein S drives oral squamous cell carcinoma tumorigenicity through regulation of AXL
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DOI: 10.18632/oncotarget.14753
Abstract: The TAM family of proto-oncogenic receptor protein tyrosine kinases, comprising of TYRO3, AXL, and MERTK, is implicated in many human cancers. Their activation leads to cancer cell proliferation, enhanced migration, invasion, and drug resistance; however… read more here.
Keywords: pros1; axl; oral squamous; squamous cell ... See more keywords
PROS1 shapes the immune-suppressive tumor microenvironment and predicts poor prognosis in glioma
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DOI: 10.3389/fimmu.2022.1052692
Abstract: Background Glioma is the most malignant cancer in the brain. As a major vitamin-K-dependent protein in the central nervous system, PROS1 not only plays a vital role in blood coagulation, and some studies have found… read more here.
Keywords: expression pros1; immune suppressive; glioma; tumor ... See more keywords
BAP1 Loss Promotes Suppressive Tumor Immune Microenvironment via Upregulation of PROS1 in Class 2 Uveal Melanomas
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DOI: 10.3390/cancers14153678
Abstract: Simple Summary Uveal melanoma is a highly metastatic cancer of the eye which is notoriously resistant to therapy. Elucidating the mechanisms of metastasis in order to devise effective therapies has been a major challenge. The… read more here.
Keywords: bap1; class; bap1 loss; tumor ... See more keywords