Protein S Enhances the Phagocytosis of Phosphatidylserine‐Exposing Erythrocytes: Implications in Sickle Cell Disease
Sign Up to like & getrecommendations! Published in 2025 at "American Journal of Hematology"
DOI: 10.1002/ajh.70117
Abstract: The major anticoagulant Protein S (PROS1) also contributes to the phagocytosis of apoptotic cells by bridging exposed phosphatidylserine (PtdSer) to the MerTK receptor on macrophages (efferocytosis). Whether PROS1 is involved in the splenic clearance of… read more here.
Keywords: enhances phagocytosis; cell disease; phagocytosis; pros1 ... See more keywords
PROS1 variant in sudden death case of pulmonary embolism caused by calcification in the inferior vena cava: The importance of postmortem genetic analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Legal medicine"
DOI: 10.1016/j.legalmed.2022.102029
Abstract: A Japanese man in his 30s died suddenly. Postmortem computed tomography and autopsy revealed a pulmonary embolism from an organizing thrombus in the inferior vena cava as the cause of death. Genomic analysis of congenital… read more here.
Keywords: analysis; genetic analysis; pulmonary embolism; death ... See more keywords
Recurrent pulmonary embolism associated with deep venous thrombosis diagnosed as protein s deficiency owing to a novel mutation in PROS1
Sign Up to like & getrecommendations! Published in 2018 at "Medicine"
DOI: 10.1097/md.0000000000010714
Abstract: Rationale: Protein S (PS) deficiency that can be inherited or acquired is an independent risk factor for venous thromboembolism (VTE). Patient concerns: In this report, we present a case of recurrent pulmonary embolism (PE) and… read more here.
Keywords: pros1; thrombosis; protein deficiency; recurrent pulmonary ... See more keywords
Protein S drives oral squamous cell carcinoma tumorigenicity through regulation of AXL
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14753
Abstract: The TAM family of proto-oncogenic receptor protein tyrosine kinases, comprising of TYRO3, AXL, and MERTK, is implicated in many human cancers. Their activation leads to cancer cell proliferation, enhanced migration, invasion, and drug resistance; however… read more here.
Keywords: pros1; axl; oral squamous; squamous cell ... See more keywords
PROS1 shapes the immune-suppressive tumor microenvironment and predicts poor prognosis in glioma
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DOI: 10.3389/fimmu.2022.1052692
Abstract: Background Glioma is the most malignant cancer in the brain. As a major vitamin-K-dependent protein in the central nervous system, PROS1 not only plays a vital role in blood coagulation, and some studies have found… read more here.
Keywords: expression pros1; immune suppressive; glioma; tumor ... See more keywords
BAP1 Loss Promotes Suppressive Tumor Immune Microenvironment via Upregulation of PROS1 in Class 2 Uveal Melanomas
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14153678
Abstract: Simple Summary Uveal melanoma is a highly metastatic cancer of the eye which is notoriously resistant to therapy. Elucidating the mechanisms of metastasis in order to devise effective therapies has been a major challenge. The… read more here.
Keywords: bap1; class; bap1 loss; tumor ... See more keywords