ProSAAS‐derived peptides are regulated by cocaine and are required for sensitization to the locomotor effects of cocaine
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DOI: 10.1111/jnc.14209
Abstract: To identify neuropeptides that are regulated by cocaine, we used a quantitative peptidomic technique to examine the relative levels of neuropeptides in several regions of mouse brain following daily intraperitoneal administration of 10 mg/kg cocaine… read more here.
Keywords: prosaas; prosaas derived; regulated cocaine; cocaine ... See more keywords
The proSAAS Chaperone Provides Neuroprotection and Attenuates Transsynaptic α-Synuclein Spread in Rodent Models of Parkinson's Disease.
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DOI: 10.3233/jpd-213053
Abstract: BACKGROUND Parkinson's disease involves aberrant aggregation of the synaptic protein alpha-synuclein (aSyn) in the nigrostriatal tract. We have previously shown that proSAAS, a small neuronal chaperone, blocks aSyn-induced dopaminergic cytotoxicity in primary nigral cultures. OBJECTIVE… read more here.
Keywords: prosaas; models parkinson; chaperone; parkinson disease ... See more keywords
ProSAAS peptide of the granin protein family in biochemical diagnostics of pheochromocytoma.
Sign Up to like & getrecommendations! Published in 2022 at "Endokrynologia Polska"
DOI: 10.5603/ep.a2022.0017
Abstract: INTRODUCTION Pheochromocytoma is a hormonally active tumour originating from neuroendocrine cells of the adrenal medulla. Chromogranin A (CgA) and peptide proSAAS belong to the family of granins and are present in neuroendocrine cells of adrenal… read more here.
Keywords: biochemical diagnostics; family; prosaas; diagnostics pheochromocytoma ... See more keywords