PRosettaC: Rosetta Based Modeling of PROTAC Mediated Ternary Complexes
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DOI: 10.1021/acs.jcim.0c00589
Abstract: Proteolysis-targeting chimeras (PROTACs), which induce degradation by recruitment of an E3 ligase to a target protein, are gaining much interest as a new pharmacological modality. However, designing PROTACs is challenging. Formation of a ternary complex… read more here.
Keywords: protein; ternary complex; ternary complexes; protac ... See more keywords