Association Between Early Prostacyclin Therapy and Extracorporeal Life Support Use in Patients With Congenital Diaphragmatic Hernia.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA pediatrics"
DOI: 10.1001/jamapediatrics.2023.0405
Abstract: Importance Prostacyclin (PGI2) is a therapeutic option to treat congenital diaphragmatic hernia (CDH)-associated pulmonary hypertension in neonates. Its use may decrease the need for extracorporeal life support (ECLS). Objective To evaluate the association of early… read more here.
Keywords: therapy; prostacyclin; ecls; life ... See more keywords
Thyroid Dysfunction in Patients with Pulmonary Artery Hypertension (PAH): The Effect of Therapies Affecting the Prostanoid Pathway
Sign Up to like & getrecommendations! Published in 2019 at "Lung"
DOI: 10.1007/s00408-019-00283-8
Abstract: Epoprostenol, a synthetic prostaglandin I2 (PGI2) analog, has been the mainstay of treatment for severe pulmonary arterial hypertension (PAH) for the last two decades. Treprostinil, another synthetic prostaglandin analog, and selexipag, an oral selective Inositol… read more here.
Keywords: hypertension pah; thyroid dysfunction; prostacyclin; dysfunction ... See more keywords
Increased prostacyclin formation after high-intensity interval training in late postmenopausal women
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Applied Physiology"
DOI: 10.1007/s00421-020-04405-6
Abstract: Purpose Aging impairs vascular function in women, with the largest detrimental effects occurring during the menopausal transition. Deficiency in the nitric oxide system has been suggested to be responsible for impairment in vascular function with… read more here.
Keywords: prostacyclin; late postmenopausal; vascular function; formation ... See more keywords
Prostacyclin reverses platelet stress fibre formation causing platelet aggregate instability
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-05817-9
Abstract: Prostacyclin (PGI2) modulates platelet activation to regulate haemostasis. Evidence has emerged to suggest that thrombi are dynamic structures with distinct areas of differing platelet activation. It was hypothesised that PGI2 could reverse platelet spreading by… read more here.
Keywords: prostacyclin; fibre formation; pgi2; formation ... See more keywords
The prostacyclin pathway in pulmonary arterial hypertension: a clinical review
Sign Up to like & getrecommendations! Published in 2017 at "Expert Review of Respiratory Medicine"
DOI: 10.1080/17476348.2017.1317599
Abstract: ABSTRACT Introduction: Prostacyclin is produced in vascular endothelial cells and acts via the IP prostacyclin receptor to cause vasodilation and inhibit smooth muscle cell proliferation and platelet aggregation. Prostacyclin production is reduced in pulmonary arterial… read more here.
Keywords: prostacyclin; prostacyclin pathway; arterial hypertension; pulmonary arterial ... See more keywords
In vivo Endocrine Secretion of Prostacyclin Following Expression of a Cyclooxygenase-1/Prostacyclin Fusion Protein in the Salivary Glands of Rats Via Nonviral Gene Therapy.
Sign Up to like & getrecommendations! Published in 2017 at "Human gene therapy"
DOI: 10.1089/hum.2017.040
Abstract: Pulmonary arterial hypertension (PAH) is a progressive disease that culminates in right heart failure and death. Prostacyclin (PGI2) and its derivatives are effective treatments for PAH when administered as continuous parenteral infusions. This treatment paradigm… read more here.
Keywords: prostacyclin; gene therapy; fusion protein; expression ... See more keywords
Abstract B35: Biomarkers for precision application of prostacyclin lung cancer chemoprevention
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.aacriaslc18-b35
Abstract: Lung cancer remains the leading cause of cancer death in the United States, and chemoprevention offers an appealing area of investigation in the face of limited therapeutic success. Improvement in endobronchial histology was demonstrated in… read more here.
Keywords: prostacyclin; chemoprevention; lung cancer; cancer ... See more keywords
Prostacyclin and EMT Pathway Markers for Monitoring Response to Lung Cancer Chemoprevention
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Prevention Research"
DOI: 10.1158/1940-6207.capr-18-0052
Abstract: Lung cancer is the leading cause of cancer death worldwide and global burden could be reduced through targeted application of chemoprevention. The development of squamous lung carcinoma has been linked with persistent, high-grade bronchial dysplasia.… read more here.
Keywords: prostacyclin; chemoprevention; lung cancer; cancer ... See more keywords
Prostacyclin as an Anticoagulant for Continuous Renal Replacement Therapy in Children
Sign Up to like & getrecommendations! Published in 2017 at "Blood Purification"
DOI: 10.1159/000452754
Abstract: Effective delivery of continuous renal replacement therapy (CRRT) depends on the longevity of the filter and circuit used in the CRRT machine. Safe and effective anticoagulation is crucial for maintaining the patency of these circuits.… read more here.
Keywords: replacement therapy; prostacyclin; continuous renal; crrt ... See more keywords
Transition from parental prostacyclin to selexipag: a case series of five pulmonary arterial hypertension patients
Sign Up to like & getrecommendations! Published in 2019 at "Pulmonary Circulation"
DOI: 10.1177/2045894019862167
Abstract: Parental prostacyclin is the only therapy with a proven survival benefit in pulmonary arterial hypertension (PAH). However, some patients are unable to tolerate continuous prostacyclin infusion because of central line infection, side effects, or sociocultural… read more here.
Keywords: prostacyclin; parental prostacyclin; transition; pulmonary arterial ... See more keywords
Clinical efficacy and safety of nebulized prostacyclin in patients with sARs-CoV-2 (prospective comparative study)
Sign Up to like & getrecommendations! Published in 2020 at "Test"
DOI: 10.22625/2072-6732-2020-12-3-34-41
Abstract: Aim. In this study we evaluated clinical effectiveness and safety of nebulized prostacyclin in patients with Novel Coronavirus Disease (SARS-CoV-2). Materials and methods: We have included 44 male patients with moderate PCR confirmed SARS-CoV-2 infection… read more here.
Keywords: prostacyclin; study; safety nebulized; nebulized prostacyclin ... See more keywords