Microsomal prostaglandin E synthase 2 deficiency is resistant to acetaminophen-induced liver injury
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Toxicology"
DOI: 10.1007/s00204-019-02543-1
Abstract: Acetaminophen (APAP)-induced liver injury is the main cause of acute liver failure. This study investigated the role of microsomal prostaglandin E synthase 2 (mPGES-2), discovered as one of the prostaglandin E2 (PGE2) synthases, in mediating… read more here.
Keywords: prostaglandin; induced liver; apap induced; liver injury ... See more keywords
Prostaglandin E2 receptor EP1 in healthy and diseased human endometrium
Sign Up to like & getrecommendations! Published in 2017 at "Histochemistry and Cell Biology"
DOI: 10.1007/s00418-017-1616-y
Abstract: Prostaglandin E2 (PGE2) is well described to be associated with both endometrial functions and disorders. The primary aim of this study was to explore the underlying mechanisms that affect the growth and function of endometrial… read more here.
Keywords: prostaglandin; intensity; endometrium; cancer ... See more keywords
A 4-week comparison of capillaroscopy changes, healing effect, and cost-effectiveness of botulinum toxin-A vs prostaglandin analog infusion in refractory digital ulcers in systemic sclerosis
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Rheumatology"
DOI: 10.1007/s10067-021-05900-7
Abstract: Systemic sclerosis (SSc) is a systemic multi-organ disease. Raynaud’s phenomenon (RP) and digital ulcers (DUs) in SSc patients can be resistant to usual treatments. We studied the clinical benefits, capillaroscopy changes, and cost-effectiveness of local… read more here.
Keywords: prostaglandin; capillaroscopy; digital ulcers; group ... See more keywords
Exposure of marine mussels to diclofenac: modulation of prostaglandin biosynthesis
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-017-9228-6
Abstract: Human pharmaceuticals, such as nonsteroidal anti-inflammatory drugs (NSAIDs), are an emerging threat to marine organisms. NSAIDs act through inhibition of cyclooxygenase (COX) conversion of arachidonic acid into prostaglandins. One experiment was carried out whereby marine… read more here.
Keywords: exposure marine; modulation; prostaglandin; exposure ... See more keywords
Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis.
Sign Up to like & getrecommendations! Published in 2021 at "Cell metabolism"
DOI: 10.1016/j.cmet.2021.03.008
Abstract: Cellular senescence is a stress or damage response that causes a permanent proliferative arrest and secretion of numerous factors with potent biological activities. This senescence-associated secretory phenotype (SASP) has been characterized largely for secreted proteins… read more here.
Keywords: senolysis; oxylipin biosynthesis; prostaglandin; senescence ... See more keywords
Use of prostaglandin E1 to treat pulmonary hypertension in congenital diaphragmatic hernia.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pediatric surgery"
DOI: 10.1016/j.jpedsurg.2018.10.039
Abstract: BACKGROUND/PURPOSE Prostaglandin E1 (PGE) has been used to maintain ductus arteriosus patency and unload the suprasystemic right ventricle (RV) in neonates with congenital diaphragmatic hernia (CDH) and severe pulmonary hypertension (PH). Here we evaluate the… read more here.
Keywords: congenital diaphragmatic; diaphragmatic hernia; prostaglandin; pulmonary hypertension ... See more keywords
A Single Radioprotective Dose of Prostaglandin E2 Blocks Irradiation-Induced Apoptotic Signaling and Early Cycling of Hematopoietic Stem Cells
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DOI: 10.1016/j.stemcr.2020.07.004
Abstract: Summary Ionizing radiation exposure results in acute and delayed bone marrow suppression. Treatment of mice with 16,16-dimethyl prostaglandin E2 (dmPGE2) prior to lethal ionizing radiation (IR) facilitates survival, but the cellular and molecular mechanisms are… read more here.
Keywords: prostaglandin; single radioprotective; stem cell; hematopoietic stem ... See more keywords
Unraveling the Molecular Details of the Complete Mechanism That Governs the Synthesis of Prostaglandin G2 Catalyzed by Cyclooxygenase-2
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DOI: 10.1021/acsomega.8b03575
Abstract: Cyclooxygenase-2 (COX-2) is the key enzyme involved in the synthesis pathway of prostaglandin G2 (PGG2) by transformation of arachidonic acid (AA). Although COX-2 is one of the principal pharmacolo... read more here.
Keywords: prostaglandin; cyclooxygenase; synthesis; unraveling molecular ... See more keywords
Prostaglandin E2 glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y6
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-02414-8
Abstract: Cyclooxygenase-2 catalyses the biosynthesis of prostaglandins from arachidonic acid but also the biosynthesis of prostaglandin glycerol esters (PG-Gs) from 2-arachidonoylglycerol. Previous studies identified PG-Gs as signalling molecules involved in inflammation. Thus, the glyceryl ester of… read more here.
Keywords: prostaglandin; receptor p2y6; pge2; receptor ... See more keywords
Effect of Vaginal Washing before Intravaginal Prostaglandin Insertion on Induction of Labor: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Perinatology"
DOI: 10.1055/s-0043-1763502
Abstract: Abstract Objective Saline vaginal douching prior to intravaginal prostaglandin application might increase the vaginal pH, leading to improvement of prostaglandin bioavailability, by which the outcomes of labor induction can be greatly improved. Thus, we aimed… read more here.
Keywords: prostaglandin; labor; prostaglandin insertion; vaginal washing ... See more keywords
Efficacy of local prostaglandin analogues for vitiligo treatment: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Clinical Pharmacology"
DOI: 10.1080/17512433.2022.2071699
Abstract: ABSTRACT Background Vitiligo is a common cutaneous depigmentation disorder. Although multiple treatment options are available, no single modality is satisfactory for all patients. Several studies have demonstrated that prostaglandin analogues can potentially treat cutaneous depigmentation,… read more here.
Keywords: prostaglandin; local prostaglandin; systematic review; analysis ... See more keywords