Prostaglandin EP2 Receptor and Cystoid Macular Edema in Phakic Posttrabeculectomy Eyes.
Sign Up to like & getrecommendations! Published in 2025 at "JAMA ophthalmology"
DOI: 10.1001/jamaophthalmol.2025.2490
Abstract: Importance Omidenepag isopropyl (OMDI), a prostaglandin EP2 receptor agonist, effectively reduces intraocular pressure but has a known risk of cystoid macular edema (CME), particularly in pseudophakic and aphakic eyes. Its safety profile in patients with… read more here.
Keywords: cystoid macular; macular edema; history; prostaglandin ep2 ... See more keywords
Prostaglandin E2-EP2/EP4 signaling induces the tumor-infiltrating Treg phenotype for tumor growth.
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2424251122
Abstract: Significance Regulatory T cells (Tregs) are enriched in the tumor microenvironment (TME) and contribute to immune evasion. These tumor-infiltrating Tregs (TI-Tregs) are highly suppressive and express a unique set of genes, which are conserved across… read more here.
Keywords: tumor infiltrating; signaling induces; ep4 signaling; tumor ... See more keywords