Prostaglandin D2 signaling in dendritic cells is critical for the development of EAE
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Autoimmunity"
DOI: 10.1016/j.jaut.2020.102508
Abstract: Abstract Priming of autoreactive T cells in lymph nodes by dendritic cells (DCs) is critical for the pathogenesis of experimental autoimmune encephalitis (EAE). DC activation reflects a balance of pro- and anti-inflammatory signals. One anti-inflammatory… read more here.
Keywords: ptgdr; prostaglandin signaling; signaling dendritic; dendritic cells ... See more keywords
Discovery of a Celecoxib Binding Site on Prostaglandin E Synthase (PTGES) with a Cleavable Chelation-Assisted Biotin Probe.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00511
Abstract: The coxibs are a subset of nonsteroidal anti-inflammatory drugs (NSAIDs) that primarily target cyclooxygenase-2 (COX-2) to inhibit prostaglandin signaling and reduce inflammation. However, mechanisms to inhibit other members of the prostaglandin signaling pathway may improve… read more here.
Keywords: celecoxib; probe; prostaglandin signaling; binding site ... See more keywords
Prostaglandin D2 signaling is not involved in the recovery of rat hind limb tendons from injury
Sign Up to like & getrecommendations! Published in 2019 at "Physiological Reports"
DOI: 10.14814/phy2.14289
Abstract: Injured tendons heal through the formation of a fibrovascular scar that has inferior mechanical properties compared to native tendon tissue. Reducing inflammation that occurs as a result of the injury could limit scar formation and… read more here.
Keywords: recovery; prostaglandin signaling; signaling involved; tendons injury ... See more keywords