Coordinated action of microsomal prostaglandin E synthase-1 and prostacyclin synthase on contact hypersensitivity.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.02.004
Abstract: Microsomal prostaglandin (PG) E synthase-1 (mPGES-1) and prostacyclin (PGI2) synthase (PGIS) are PG terminal synthases that work downstream of cyclooxygenase and synthesize PGE2 and PGI2, respectively. Although the involvement of PG receptors in acquired cutaneous… read more here.
Keywords: microsomal prostaglandin; prostaglandin synthase; synthase; contact hypersensitivity ... See more keywords
Sample-dependent diagnostic accuracy of prostaglandin D synthase in cerebrospinal fluid leak.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical biochemistry"
DOI: 10.1016/j.clinbiochem.2016.09.006
Abstract: BACKGROUND Prostaglandin D2 synthase, commonly known as β-trace protein (βTP), is an excellent biomarker for the assessment of cerebrospinal fluid (CSF) leaks. Despite being widely used, the limits for the diagnostic values of βTP are… read more here.
Keywords: sample; fluid; diagnostic accuracy; prostaglandin synthase ... See more keywords
Discovery of a Celecoxib Binding Site on Prostaglandin E Synthase (PTGES) with a Cleavable Chelation-Assisted Biotin Probe.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00511
Abstract: The coxibs are a subset of nonsteroidal anti-inflammatory drugs (NSAIDs) that primarily target cyclooxygenase-2 (COX-2) to inhibit prostaglandin signaling and reduce inflammation. However, mechanisms to inhibit other members of the prostaglandin signaling pathway may improve… read more here.
Keywords: celecoxib; probe; prostaglandin signaling; binding site ... See more keywords
Abundant neuroprotective chaperone Lipocalin-type prostaglandin D synthase (L-PGDS) disassembles the Amyloid-β fibrils
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-48819-5
Abstract: Misfolding of Amyloid β (Aβ) peptides leads to the formation of extracellular amyloid plaques. Molecular chaperones can facilitate the refolding or degradation of such misfolded proteins. Here, for the first time, we report the unique… read more here.
Keywords: pgds; prostaglandin synthase; synthase pgds; type prostaglandin ... See more keywords
Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2017.1344218
Abstract: ABSTRACT Introduction: Microsomal prostaglandin E2 synthase-1 (mPGES-1) catalyzes the terminal step of prostaglandin E2 (PGE2) generation. It is strongly upregulated in inflamed tissues and overexpressed in tumors and it has been recognized as a key… read more here.
Keywords: microsomal prostaglandin; prostaglandin synthase; inflammatory; mpges inhibitors ... See more keywords
The microsomal prostaglandin E synthase-1/PGE2 axis induces recovery from ischemia via recruitment of regulatory T cells.
Sign Up to like & getrecommendations! Published in 2022 at "Cardiovascular research"
DOI: 10.1093/cvr/cvac137
Abstract: AIMS Microsomal prostaglandin E synthase-1 (mPGES-1)/prostaglandin E2 (PGE2) induces angiogenesis through the prostaglandin E2 receptor (EP1-4). Among immune cells, regulatory T cells (Tregs), which inhibit immune responses, have been implicated in angiogenesis, and PGE2 is… read more here.
Keywords: ischemia; regulatory cells; prostaglandin synthase; recovery ischemia ... See more keywords
Prosurvival effect of cumulus prostaglandin G/H synthase 2/prostaglandin2 signaling on bovine blastocyst: impact on in vivo posthatching development†
Sign Up to like & getrecommendations! Published in 2017 at "Biology of Reproduction"
DOI: 10.1095/biolreprod.116.145367
Abstract: Abstract Apoptotic activity is a common physiological process which culminates at the blastocyst stage in the preimplantation embryo of many mammals. The degree of embryonic cell death can be influenced by the oocyte microenvironment. However,… read more here.
Keywords: posthatching development; vivo posthatching; pge2; prostaglandin synthase ... See more keywords
Microsomal prostaglandin E synthase-1 inhibition prevents adverse cardiac remodeling after myocardial infarction in mice.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of pharmacology"
DOI: 10.1111/bph.16061
Abstract: BACKGROUND Heart failure with reduced ejection fraction (HFrEF) is a major consequence of myocardial infarction (MI). We have previously demonstrated that the microsomal prostaglandin E synthase-1 (mPGES-1)/PGE2 pathway constrains reperfusion injury after acute myocardial ischemia.… read more here.
Keywords: inhibition; myocardial infarction; adverse cardiac; prostaglandin synthase ... See more keywords
Gene Deletion of Microsomal Prostaglandin E Synthase-1 Suppresses Chemically Induced Skin Carcinogenesis
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DOI: 10.21873/anticanres.14888
Abstract: Background/Aim: Microsomal prostaglandin (PG) E synthase-1 (mPGES-1) is a terminal enzyme in PGE2 synthesis and highly expressed in several cancers. In this study, to reveal the involvement of mPGES-1 in skin carcinogenesis, the effect of… read more here.
Keywords: microsomal prostaglandin; skin carcinogenesis; prostaglandin synthase; induced skin ... See more keywords
Microsomal Prostaglandin E Synthase-1 and -2: Emerging Targets in Non-Alcoholic Fatty Liver Disease
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24033049
Abstract: Nonalcoholic fatty liver disease (NAFLD) affects a substantial proportion of the general population and is even more prevalent in obese and diabetic patients. NAFLD, and particularly the more advanced manifestation of the disease, nonalcoholic steatohepatitis… read more here.
Keywords: microsomal prostaglandin; liver disease; prostaglandin synthase; fatty liver ... See more keywords