Phenolsulfonphthalein as a surrogate substrate to assess altered function of the prostaglandin transporter SLCO2A1.
Sign Up to like & getrecommendations! Published in 2022 at "Drug metabolism and pharmacokinetics"
DOI: 10.1016/j.dmpk.2022.100452
Abstract: The prostaglandin (PG) transporter SLCO2A1 regulates PGE2 signaling and interacts with many drugs, and SLCO2A1 defects is associated with PG metabolic disorders. This study aimed to characterize a non-metabolic phenolsulfonphthalein (PSP) transport mediated by SLCO2A1.… read more here.
Keywords: prostaglandin transporter; slco2a1; function; transporter slco2a1 ... See more keywords
Toxicological implication of prostaglandin transporter SLCO2A1 inhibition by cigarette smoke in exacerbation of lung inflammation.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2020.115201
Abstract: We reported that bleomycin (BLM)-induced pulmonary fibrosis was exacerbated in the prostaglandin transporter gene (Slco2a1)-deficient mice (Slco2a1(-/-)). Because cigarette smoke (CS) contributes to creating a profibrotic milieu in the respiratory region, the present study aimed… read more here.
Keywords: cigarette smoke; bal fluid; inflammation; slco2a1 ... See more keywords
A novel mutation in the SLCO2A1 gene, encoding a prostaglandin transporter, induces chronic enteropathy
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0241869
Abstract: Chronic enteropathy associated with SLCO2A1 gene (CEAS) is caused by loss-of-function mutations in SLCO2A1, which encodes a prostaglandin (PG) transporter. In this study, we report a sibling case of CEAS with a novel pathogenic variant… read more here.
Keywords: chronic enteropathy; slco2a1; slco2a1 gene; prostaglandin transporter ... See more keywords